Immunizing against Anogenital Cancer: HPV Vaccines

First Generation Vaccines The non-enveloped virus capsid is comprised of 72 pentamers (capsomeres) of the major capsid protein L1, arranged into a T = 7d icosahedral lattice, with an additional 12-36 L2 proteins located within the capsid shell [6]. [...]refrigeration is required during shipping and storage, posing logistical problems in areas lacking appropriate infrastructure.\n E6 and E7 are most often targeted because they are expressed by all HPV-infected cells and are required for the viability of cancer cells [18].