An Antibody Screen of a Plasmodium vivax Antigen Library Identifies Novel Merozoite Proteins Associated with Clinical Protection

Elimination of Plasmodium vivax malaria would be greatly facilitated by the development of an effective vaccine. A comprehensive and systematic characterization of antibodies to P. vivax antigens in exposed populations is useful in guiding rational vaccine design. In this study, we investigated anti...

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Veröffentlicht in:	PLoS neglected tropical diseases 2016-05, Vol.10 (5), p.e0004639-e0004639
Hauptverfasser:	França, Camila T, Hostetler, Jessica B, Sharma, Sumana, White, Michael T, Lin, Enmoore, Kiniboro, Benson, Waltmann, Andreea, Darcy, Andrew W, Li Wai Suen, Connie S N, Siba, Peter, King, Christopher L, Rayner, Julian C, Fairhurst, Rick M, Mueller, Ivo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Animals Antibodies, Protozoan - blood Antibodies, Protozoan - immunology Antigens Antigens, Protozoan - blood Antigens, Protozoan - immunology Biology and Life Sciences Biomarkers - blood Candidates Child Cohort Studies Drug Discovery Female Funding High-Throughput Screening Assays Humans Immune response Immune status Immunity, Innate Immunogenicity Immunoglobulins Infant Infections Libraries Malaria Malaria vaccines Malaria, Vivax - epidemiology Malaria, Vivax - immunology Malaria, Vivax - parasitology Malaria, Vivax - prevention & control Malària Medical research Medicine and Health Sciences Melanesia - epidemiology Merozoites - chemistry Merozoites - immunology Middle Aged Mortality Papua New Guinea - epidemiology Parasite antigens Peptide Library Plasmodium vivax Plasmodium vivax - chemistry Plasmodium vivax - genetics Plasmodium vivax - immunology Proteins Protozoan Proteins - chemistry Protozoan Proteins - immunology Protozoan Proteins - isolation & purification Research and Analysis Methods Studies Tropical diseases Vaccines Vector-borne diseases Young Adult
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Zusammenfassung:	Elimination of Plasmodium vivax malaria would be greatly facilitated by the development of an effective vaccine. A comprehensive and systematic characterization of antibodies to P. vivax antigens in exposed populations is useful in guiding rational vaccine design. In this study, we investigated antibodies to a large library of P. vivax entire ectodomain merozoite proteins in 2 Asia-Pacific populations, analysing the relationship of antibody levels with markers of current and cumulative malaria exposure, and socioeconomic and clinical indicators. 29 antigenic targets of natural immunity were identified. Of these, 12 highly-immunogenic proteins were strongly associated with age and thus cumulative lifetime exposure in Solomon Islanders (P
ISSN:	1935-2735 1935-2727 1935-2735
DOI:	10.1371/journal.pntd.0004639