Diagnostic Accuracy of Lateral Flow Urine LAM Assay for TB Screening of Adults with Advanced Immunosuppression Attending Routine HIV Care in South Africa

We assessed the diagnostic accuracy of Determine TB-LAM (LF-LAM) to screen for tuberculosis among ambulatory adults established in HIV care in South Africa. A systematic sample of adults attending for HIV care, regardless of symptomatology, were enrolled in the XPHACTOR study, which tested a novel a...

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Veröffentlicht in:	PloS one 2016-06, Vol.11 (6), p.e0156866-e0156866
Hauptverfasser:	Hanifa, Yasmeen, Fielding, Katherine L, Chihota, Violet N, Adonis, Lungiswa, Charalambous, Salome, Karstaedt, Alan, McCarthy, Kerrigan, Nicol, Mark P, Ndlovu, Nontobeko T, Sahid, Faieza, Churchyard, Gavin J, Grant, Alison D
Format:	Artikel
Sprache:	eng
Schlagworte:	Accuracy Adult Adults Anti-Retroviral Agents - therapeutic use Antiretroviral drugs Biology and Life Sciences Body mass Body mass index Body size Body weight loss CD4 antigen Complications and side effects Cough Diagnosis Diagnostic systems Drug therapy Female Fever HIV HIV infections HIV Infections - drug therapy Hospitals Human immunodeficiency virus Humans Hygiene Immunosuppression Laboratories Lentivirus Lipopolysaccharides - urine Male Medical diagnosis Medical screening Medicine Medicine and Health Sciences Middle Aged Mycobacterium Mycobacterium tuberculosis Point-of-Care Systems Prospective Studies Retroviridae Risk factors Sensitivity Sensitivity and Specificity South Africa Sputum Tuberculosis Tuberculosis, Pulmonary - diagnosis Tuberculosis, Pulmonary - metabolism Urinalysis Urine
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Zusammenfassung:	We assessed the diagnostic accuracy of Determine TB-LAM (LF-LAM) to screen for tuberculosis among ambulatory adults established in HIV care in South Africa. A systematic sample of adults attending for HIV care, regardless of symptomatology, were enrolled in the XPHACTOR study, which tested a novel algorithm for prioritising investigation with Xpert MTB/RIF. In this substudy, restricted to participants with enrolment CD4
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0156866