Maternal Smoking during Pregnancy and DNA-Methylation in Children at Age 5.5 Years: Epigenome-Wide-Analysis in the European Childhood Obesity Project (CHOP)-Study

Mounting evidence links prenatal exposure to maternal tobacco smoking with disruption of DNA methylation (DNAm) profile in the blood of infants. However, data on the postnatal stability of such DNAm signatures in childhood, as assessed by Epigenome Wide Association Studies (EWAS), are scarce. Object...

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Veröffentlicht in:	PloS one 2016-05, Vol.11 (5), p.e0155554-e0155554
Hauptverfasser:	Rzehak, Peter, Saffery, Richard, Reischl, Eva, Covic, Marcela, Wahl, Simone, Grote, Veit, Xhonneux, Annick, Langhendries, Jean-Paul, Ferre, Natalia, Closa-Monasterolo, Ricardo, Verduci, Elvira, Riva, Enrica, Socha, Piotr, Gruszfeld, Dariusz, Koletzko, Berthold
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Bioinformatics Biological effects Biology and life sciences Blood Child Childhood Childhood obesity Children CpG islands CpG Islands - genetics Deoxyribonucleic acid DNA DNA methylation DNA Methylation - genetics DNA probes Epidemiology Epigenesis, Genetic Epigenetics Europe Exposure Female Gene Regulatory Networks Genes Genetic aspects Genome-wide association studies Genome-Wide Association Study Genomes Genomics Gestation Health aspects Hospitals Humans Identification and classification Infants Intrauterine exposure Male Medicine Medicine and Health Sciences Metabolism Methods Nicotine Obesity Obesity - genetics Phenotypes Pregnancy Prenatal experience Prenatal exposure Prenatal Exposure Delayed Effects - genetics Probes Regression analysis Risk factors Signatures Smoke Smoking Smoking - genetics Smoking in pregnancy Stability analysis Studies Tobacco Tobacco smoke Tobacco smoking
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