Functional and Prognostic Implications of the Main Pulmonary Artery Diameter to Aorta Diameter Ratio from Chest Computed Tomography in Korean COPD Patients
The ratio of the diameter of the main pulmonary artery (mPA) to the diameter of the aorta (Ao) on chest computed tomography is associated with diverse clinical conditions. Herein, we determined the functional and prognostic implications of the mPA/Ao ratio in Korean chronic obstructive pulmonary dis...
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| creator | Chung, Kyung Soo Kim, Young Sam Kim, Se Kyu Kim, Ha Yan Lee, Sang Min Seo, Joon Beom Oh, Yeon Mok Jung, Ji Ye Lee, Sang-Do |
| description | The ratio of the diameter of the main pulmonary artery (mPA) to the diameter of the aorta (Ao) on chest computed tomography is associated with diverse clinical conditions. Herein, we determined the functional and prognostic implications of the mPA/Ao ratio in Korean chronic obstructive pulmonary disease (COPD) patients.
The study population comprised 226 chronic obstructive pulmonary disease patients from the Korean Obstructive Lung Disease cohort who underwent chest computed tomography. We analyzed the relationships between the clinical characteristics, including pulmonary function, echocardiography findings, St. George's Respiratory Questionnaire, 6-minute walking (6MW) distance, and exacerbation with the mPA, Ao, and mPA/Ao ratio.
The mean age was 65.8 years, and 219 (96.9%) patients were male. The mean FEV1% predicted and FEV1/FVC ratio were 61.2% and 47.3%, respectively. The mean mPA and Ao were 23.7 and 36.4 mm, respectively, and the mPA/Ao ratio was 0.66. The mPA/Ao ratio correlated negatively with the 6MW distance (G = -0.133, P = 0.025) and positively with the right ventricular pressure (G = 0.323, P = 0.001). After adjustment for potential confounders, the mPA/Ao ratio was significantly associated with 6MW distance (β = -107.7, P = 0.017). Moreover, an mPA/Ao ratio >0.8 was a significant predictor of exacerbation at the 1-year (odds ratio 2.12, 95% confidence interval 1.27-3.52) and 3-year follow-ups (odds ratio 2.04, 95% confidence interval 1.42-2.90).
The mPA/Ao ratio is an independent predictor of exercise capacity and an mPA/Ao ratio >0.8 is a significant risk factor of COPD exacerbation. |
| doi_str_mv | 10.1371/journal.pone.0154584 |
| format | Article |
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The study population comprised 226 chronic obstructive pulmonary disease patients from the Korean Obstructive Lung Disease cohort who underwent chest computed tomography. We analyzed the relationships between the clinical characteristics, including pulmonary function, echocardiography findings, St. George's Respiratory Questionnaire, 6-minute walking (6MW) distance, and exacerbation with the mPA, Ao, and mPA/Ao ratio.
The mean age was 65.8 years, and 219 (96.9%) patients were male. The mean FEV1% predicted and FEV1/FVC ratio were 61.2% and 47.3%, respectively. The mean mPA and Ao were 23.7 and 36.4 mm, respectively, and the mPA/Ao ratio was 0.66. The mPA/Ao ratio correlated negatively with the 6MW distance (G = -0.133, P = 0.025) and positively with the right ventricular pressure (G = 0.323, P = 0.001). After adjustment for potential confounders, the mPA/Ao ratio was significantly associated with 6MW distance (β = -107.7, P = 0.017). Moreover, an mPA/Ao ratio >0.8 was a significant predictor of exacerbation at the 1-year (odds ratio 2.12, 95% confidence interval 1.27-3.52) and 3-year follow-ups (odds ratio 2.04, 95% confidence interval 1.42-2.90).
The mPA/Ao ratio is an independent predictor of exercise capacity and an mPA/Ao ratio >0.8 is a significant risk factor of COPD exacerbation.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0154584</identifier><identifier>PMID: 27152915</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Aorta ; Aorta - diagnostic imaging ; Aorta - pathology ; Biology and Life Sciences ; Cardiovascular disease ; CAT scans ; Chest ; Chronic obstructive lung disease ; Chronic obstructive pulmonary disease ; Computation ; Computed tomography ; Confidence intervals ; Coronary vessels ; Critical care ; Development and progression ; Dyspnea ; Echocardiography ; Emergency medical care ; Female ; Heart ; Hospitals ; Humans ; Internal medicine ; Lung diseases ; Male ; Medical imaging ; Medical prognosis ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Mortality ; Obstructive lung disease ; Patients ; Physiological aspects ; Population studies ; Prognosis ; Pulmonary arteries ; Pulmonary artery ; Pulmonary Artery - diagnostic imaging ; Pulmonary Artery - pathology ; Pulmonary Disease, Chronic Obstructive - diagnostic imaging ; Pulmonary functions ; Pulmonary hypertension ; Republic of Korea ; Research and Analysis Methods ; Respiratory function ; Risk factors ; Tomography, X-Ray Computed - methods ; Transplants & implants ; Ventricle ; Walking</subject><ispartof>PloS one, 2016-05, Vol.11 (5), p.e0154584-e0154584</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Chung et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Chung et al 2016 Chung et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c791t-8797556c14a20d24b233d8e5eb4845766398b7d11b54db43ad33f57e98af52d53</citedby><cites>FETCH-LOGICAL-c791t-8797556c14a20d24b233d8e5eb4845766398b7d11b54db43ad33f57e98af52d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859521/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859521/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27152915$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chung, Kyung Soo</creatorcontrib><creatorcontrib>Kim, Young Sam</creatorcontrib><creatorcontrib>Kim, Se Kyu</creatorcontrib><creatorcontrib>Kim, Ha Yan</creatorcontrib><creatorcontrib>Lee, Sang Min</creatorcontrib><creatorcontrib>Seo, Joon Beom</creatorcontrib><creatorcontrib>Oh, Yeon Mok</creatorcontrib><creatorcontrib>Jung, Ji Ye</creatorcontrib><creatorcontrib>Lee, Sang-Do</creatorcontrib><creatorcontrib>Korean Obstructive Lung Disease study group</creatorcontrib><title>Functional and Prognostic Implications of the Main Pulmonary Artery Diameter to Aorta Diameter Ratio from Chest Computed Tomography in Korean COPD Patients</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The ratio of the diameter of the main pulmonary artery (mPA) to the diameter of the aorta (Ao) on chest computed tomography is associated with diverse clinical conditions. Herein, we determined the functional and prognostic implications of the mPA/Ao ratio in Korean chronic obstructive pulmonary disease (COPD) patients.
The study population comprised 226 chronic obstructive pulmonary disease patients from the Korean Obstructive Lung Disease cohort who underwent chest computed tomography. We analyzed the relationships between the clinical characteristics, including pulmonary function, echocardiography findings, St. George's Respiratory Questionnaire, 6-minute walking (6MW) distance, and exacerbation with the mPA, Ao, and mPA/Ao ratio.
The mean age was 65.8 years, and 219 (96.9%) patients were male. The mean FEV1% predicted and FEV1/FVC ratio were 61.2% and 47.3%, respectively. The mean mPA and Ao were 23.7 and 36.4 mm, respectively, and the mPA/Ao ratio was 0.66. The mPA/Ao ratio correlated negatively with the 6MW distance (G = -0.133, P = 0.025) and positively with the right ventricular pressure (G = 0.323, P = 0.001). After adjustment for potential confounders, the mPA/Ao ratio was significantly associated with 6MW distance (β = -107.7, P = 0.017). Moreover, an mPA/Ao ratio >0.8 was a significant predictor of exacerbation at the 1-year (odds ratio 2.12, 95% confidence interval 1.27-3.52) and 3-year follow-ups (odds ratio 2.04, 95% confidence interval 1.42-2.90).
The mPA/Ao ratio is an independent predictor of exercise capacity and an mPA/Ao ratio >0.8 is a significant risk factor of COPD exacerbation.</description><subject>Aged</subject><subject>Aorta</subject><subject>Aorta - diagnostic imaging</subject><subject>Aorta - pathology</subject><subject>Biology and Life Sciences</subject><subject>Cardiovascular disease</subject><subject>CAT scans</subject><subject>Chest</subject><subject>Chronic obstructive lung disease</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Computation</subject><subject>Computed tomography</subject><subject>Confidence intervals</subject><subject>Coronary vessels</subject><subject>Critical care</subject><subject>Development and progression</subject><subject>Dyspnea</subject><subject>Echocardiography</subject><subject>Emergency medical care</subject><subject>Female</subject><subject>Heart</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Internal medicine</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Obstructive lung disease</subject><subject>Patients</subject><subject>Physiological aspects</subject><subject>Population studies</subject><subject>Prognosis</subject><subject>Pulmonary arteries</subject><subject>Pulmonary artery</subject><subject>Pulmonary Artery - diagnostic imaging</subject><subject>Pulmonary Artery - pathology</subject><subject>Pulmonary Disease, Chronic Obstructive - diagnostic imaging</subject><subject>Pulmonary functions</subject><subject>Pulmonary hypertension</subject><subject>Republic of Korea</subject><subject>Research and Analysis Methods</subject><subject>Respiratory function</subject><subject>Risk factors</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Transplants & implants</subject><subject>Ventricle</subject><subject>Walking</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9Fu0zAUhiMEYqPwBggsISG4aLFjO4lvJlUdg4qhVmNwazmOk3hK4mI7iD0LL4uzZqNBk0C-sHX8_b99jn2i6DmCC4RT9O7K9LYTzWJnOrWAiBKakQfRMWI4nicxxA8P1kfRE-euIKQ4S5LH0VGcIhozRI-jX2d9J702wQmIrgBba6rOOK8lWLe7RksxbDpgSuBrBT4L3YFt37RBYK_B0noVplMtWhVWwBuwNNaLP5GLQQ9Ka1qwqpXzYGXaXe9VAS5NayordvU1CJ6fjFWiA6vN9hRsg0Z13j2NHpWicerZOM-ir2fvL1cf5-ebD-vV8nwuU4b8PEtZSmkiERExLGKSxxgXmaIqJxmhaZJgluVpgVBOSZETLAqMS5oqlomSxgXFs-jl3nfXGMfHujqO0iyNaUKD3Sxa74nCiCu-s7oN2XMjNL8JGFtxYUPNGsUVQpIksEwYwyQuylyVkiqZU4yVLMngdTKe1uetKmTI1IpmYjrd6XTNK_ODk4wyGqNg8GY0sOZ7H2rKW-2kahrRKdOHe2eQUogYhP9GQ4oMU0ZYQF_9hd5fiJGqRMhVd6UJV5SDKV-SkGIKE5wFanEPFUahWi3Dfy11iE8EbyeCwHj101eid46vv1z8P7v5NmVfH7C1Eo2vnWn6mz89BckelNY4Z1V59x4I8qHdbqvBh3bjY7sF2YvDt7wT3fYX_g1qAyW7</recordid><startdate>20160506</startdate><enddate>20160506</enddate><creator>Chung, Kyung Soo</creator><creator>Kim, Young Sam</creator><creator>Kim, Se Kyu</creator><creator>Kim, Ha Yan</creator><creator>Lee, Sang Min</creator><creator>Seo, Joon Beom</creator><creator>Oh, Yeon Mok</creator><creator>Jung, Ji Ye</creator><creator>Lee, Sang-Do</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20160506</creationdate><title>Functional and Prognostic Implications of the Main Pulmonary Artery Diameter to Aorta Diameter Ratio from Chest Computed Tomography in Korean COPD Patients</title><author>Chung, Kyung Soo ; Kim, Young Sam ; Kim, Se Kyu ; Kim, Ha Yan ; Lee, Sang Min ; Seo, Joon Beom ; Oh, Yeon Mok ; Jung, Ji Ye ; Lee, Sang-Do</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c791t-8797556c14a20d24b233d8e5eb4845766398b7d11b54db43ad33f57e98af52d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Aorta</topic><topic>Aorta - diagnostic imaging</topic><topic>Aorta - pathology</topic><topic>Biology and Life Sciences</topic><topic>Cardiovascular disease</topic><topic>CAT scans</topic><topic>Chest</topic><topic>Chronic obstructive lung disease</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Computation</topic><topic>Computed tomography</topic><topic>Confidence intervals</topic><topic>Coronary vessels</topic><topic>Critical care</topic><topic>Development and progression</topic><topic>Dyspnea</topic><topic>Echocardiography</topic><topic>Emergency medical care</topic><topic>Female</topic><topic>Heart</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Internal medicine</topic><topic>Lung diseases</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Obstructive lung disease</topic><topic>Patients</topic><topic>Physiological aspects</topic><topic>Population studies</topic><topic>Prognosis</topic><topic>Pulmonary arteries</topic><topic>Pulmonary artery</topic><topic>Pulmonary Artery - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chung, Kyung Soo</au><au>Kim, Young Sam</au><au>Kim, Se Kyu</au><au>Kim, Ha Yan</au><au>Lee, Sang Min</au><au>Seo, Joon Beom</au><au>Oh, Yeon Mok</au><au>Jung, Ji Ye</au><au>Lee, Sang-Do</au><aucorp>Korean Obstructive Lung Disease study group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional and Prognostic Implications of the Main Pulmonary Artery Diameter to Aorta Diameter Ratio from Chest Computed Tomography in Korean COPD Patients</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-05-06</date><risdate>2016</risdate><volume>11</volume><issue>5</issue><spage>e0154584</spage><epage>e0154584</epage><pages>e0154584-e0154584</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The ratio of the diameter of the main pulmonary artery (mPA) to the diameter of the aorta (Ao) on chest computed tomography is associated with diverse clinical conditions. Herein, we determined the functional and prognostic implications of the mPA/Ao ratio in Korean chronic obstructive pulmonary disease (COPD) patients.
The study population comprised 226 chronic obstructive pulmonary disease patients from the Korean Obstructive Lung Disease cohort who underwent chest computed tomography. We analyzed the relationships between the clinical characteristics, including pulmonary function, echocardiography findings, St. George's Respiratory Questionnaire, 6-minute walking (6MW) distance, and exacerbation with the mPA, Ao, and mPA/Ao ratio.
The mean age was 65.8 years, and 219 (96.9%) patients were male. The mean FEV1% predicted and FEV1/FVC ratio were 61.2% and 47.3%, respectively. The mean mPA and Ao were 23.7 and 36.4 mm, respectively, and the mPA/Ao ratio was 0.66. The mPA/Ao ratio correlated negatively with the 6MW distance (G = -0.133, P = 0.025) and positively with the right ventricular pressure (G = 0.323, P = 0.001). After adjustment for potential confounders, the mPA/Ao ratio was significantly associated with 6MW distance (β = -107.7, P = 0.017). Moreover, an mPA/Ao ratio >0.8 was a significant predictor of exacerbation at the 1-year (odds ratio 2.12, 95% confidence interval 1.27-3.52) and 3-year follow-ups (odds ratio 2.04, 95% confidence interval 1.42-2.90).
The mPA/Ao ratio is an independent predictor of exercise capacity and an mPA/Ao ratio >0.8 is a significant risk factor of COPD exacerbation.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27152915</pmid><doi>10.1371/journal.pone.0154584</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2016-05, Vol.11 (5), p.e0154584-e0154584 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1787256523 |
| source | PubMed (Medline); MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Aged Aorta Aorta - diagnostic imaging Aorta - pathology Biology and Life Sciences Cardiovascular disease CAT scans Chest Chronic obstructive lung disease Chronic obstructive pulmonary disease Computation Computed tomography Confidence intervals Coronary vessels Critical care Development and progression Dyspnea Echocardiography Emergency medical care Female Heart Hospitals Humans Internal medicine Lung diseases Male Medical imaging Medical prognosis Medicine Medicine and Health Sciences Middle Aged Mortality Obstructive lung disease Patients Physiological aspects Population studies Prognosis Pulmonary arteries Pulmonary artery Pulmonary Artery - diagnostic imaging Pulmonary Artery - pathology Pulmonary Disease, Chronic Obstructive - diagnostic imaging Pulmonary functions Pulmonary hypertension Republic of Korea Research and Analysis Methods Respiratory function Risk factors Tomography, X-Ray Computed - methods Transplants & implants Ventricle Walking |
| title | Functional and Prognostic Implications of the Main Pulmonary Artery Diameter to Aorta Diameter Ratio from Chest Computed Tomography in Korean COPD Patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T08%3A39%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Functional%20and%20Prognostic%20Implications%20of%20the%20Main%20Pulmonary%20Artery%20Diameter%20to%20Aorta%20Diameter%20Ratio%20from%20Chest%20Computed%20Tomography%20in%20Korean%20COPD%20Patients&rft.jtitle=PloS%20one&rft.au=Chung,%20Kyung%20Soo&rft.aucorp=Korean%20Obstructive%20Lung%20Disease%20study%20group&rft.date=2016-05-06&rft.volume=11&rft.issue=5&rft.spage=e0154584&rft.epage=e0154584&rft.pages=e0154584-e0154584&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0154584&rft_dat=%3Cgale_plos_%3EA453370638%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1787256523&rft_id=info:pmid/27152915&rft_galeid=A453370638&rft_doaj_id=oai_doaj_org_article_e11c460f699342dfbefc5ecb533ecf43&rfr_iscdi=true |