Go Forth and Colonize: Dispersal from Clinically Important Microbial Biofilms

[...]dispersed cells were found to be four times more resistant to fluconazole [34]. Since none of the currently available classes of drugs (perhaps with the exception of echinocandins) inhibit biofilms or biofilm dispersal, there is an urgent need to discover newer antifungal molecules that can perhaps do both. [...]of innumerable factors, there is a high degree of complexity that distinguishes biofilms in vivo from those formed in vitro, including environmental parameters, interaction with host cells, and presence of other species of commensal microbes.