The Role of Metformin Response in Lipid Metabolism in Patients with Recent-Onset Type 2 Diabetes: HbA1c Level as a Criterion for Designating Patients as Responders or Nonresponders to Metformin

In this study, we investigated whether response to metformin, the most frequently drug for diabetes treatment, influences the therapeutic effects of antilipidemic medication in newly diagnosed patients with type 2 diabetes mellitus (T2DM). A total of 150 patients with T2DM were classified into two g...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2016-03, Vol.11 (3), p.e0151543-e0151543
Hauptverfasser:	Kashi, Zahra, Mahrooz, Abdolkarim, Kianmehr, Anvarsadat, Alizadeh, Ahad
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis Antidiabetics Atorvastatin Atorvastatin - pharmacokinetics Atorvastatin - pharmacology Atorvastatin - therapeutic use Biochemistry Biological Transport - drug effects Biology and Life Sciences Blood Glucose - analysis Blood Pressure - drug effects Body mass Body Mass Index Care and treatment Cholesterol Cholesterol, HDL - blood Cholesterol, LDL - blood Complications and side effects Dependent variables Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Dosage and administration Drug dosages Drug Monitoring Drug Resistance Drug Synergism Drug therapy Drug Therapy, Combination Drugs Dyslipidemias - blood Dyslipidemias - drug therapy Dyslipidemias - etiology Epidemiology Family medical history Female Gemfibrozil Gemfibrozil - pharmacology Gemfibrozil - therapeutic use Genetic aspects Glucose Glycated Hemoglobin A - analysis Hemoglobin High density lipoprotein Humans Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Hypolipidemic Agents - pharmacology Hypolipidemic Agents - therapeutic use Independent variables Insulin resistance Kinases Lipid metabolism Lipids Lipoproteins Low density lipoprotein Male Markers Medicine and Health Sciences Metabolism Metformin Metformin - pharmacology Metformin - therapeutic use Middle Aged Multivariate analysis Patients Physiological aspects Reduction Statistical analysis Studies Type 2 diabetes Womens health
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	In this study, we investigated whether response to metformin, the most frequently drug for diabetes treatment, influences the therapeutic effects of antilipidemic medication in newly diagnosed patients with type 2 diabetes mellitus (T2DM). A total of 150 patients with T2DM were classified into two groups following 3 months of metformin therapy (1000 mg twice daily): responders (patients showing ≥1% reduction in HbA1c from baseline) and nonresponders (patients showing
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0151543