Hepatitis B and C Co-Infection in HIV Patients from the TREAT Asia HIV Observational Database: Analysis of Risk Factors and Survival

We assessed the effects of hepatitis B (HBV) or hepatitis C (HCV) co-infection on outcomes of antiretroviral therapy (ART) in HIV-infected patients enrolled in the TREAT Asia HIV Observational Database (TAHOD), a multi-center cohort of HIV-infected patients in the Asia-Pacific region. Patients testi...

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Veröffentlicht in:	PloS one 2016-03, Vol.11 (3), p.e0150512-e0150512
Hauptverfasser:	Chen, Marcelo, Wong, Wing-Wai, Law, Matthew G, Kiertiburanakul, Sasisopin, Yunihastuti, Evy, Merati, Tuti Parwati, Lim, Poh Lian, Chaiwarith, Romanee, Phanuphak, Praphan, Lee, Man Po, Kumarasamy, Nagalingeswaran, Saphonn, Vonthanak, Ditangco, Rossana, Sim, Benedict L H, Nguyen, Kinh Van, Pujari, Sanjay, Kamarulzaman, Adeeba, Zhang, Fujie, Pham, Thuy Thanh, Choi, Jun Yong, Oka, Shinichi, Kantipong, Pacharee, Mustafa, Mahiran, Ratanasuwan, Winai, Durier, Nicolas, Chen, Yi-Ming Arthur
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adult Age AIDS Anti-Retroviral Agents - therapeutic use Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Antiretroviral Therapy, Highly Active Asia - epidemiology Biology and Life Sciences CD4 antigen CD4 Lymphocyte Count Cohort Studies Coinfection - complications Coinfection - epidemiology Community colleges Drug therapy Female Health aspects Health risks Health sciences Hepatitis Hepatitis B Hepatitis B - complications Hepatitis B - epidemiology Hepatitis B surface antigen Hepatitis B virus Hepatitis C Hepatitis C - complications Hepatitis C - epidemiology Hepatitis C virus HIV HIV infections HIV Infections - complications HIV Infections - drug therapy HIV Infections - epidemiology HIV patients HIV-1 - drug effects HIV-1 - isolation & purification Hospitals Human immunodeficiency virus Humans Immune response Immunology Infections Infectious diseases Male Medical research Medicine Medicine and Health Sciences Middle Aged Mortality Multivariate analysis Patient outcomes Patients People and Places Recovery Regression analysis Regression models Ribonucleic acid Risk analysis Risk Factors RNA Survival Survival Analysis Test procedures Treatment Outcome
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Zusammenfassung:	We assessed the effects of hepatitis B (HBV) or hepatitis C (HCV) co-infection on outcomes of antiretroviral therapy (ART) in HIV-infected patients enrolled in the TREAT Asia HIV Observational Database (TAHOD), a multi-center cohort of HIV-infected patients in the Asia-Pacific region. Patients testing HBs antigen (Ag) or HCV antibody (Ab) positive within enrollment into TAHOD were considered HBV or HCV co-infected. Factors associated with HBV and/or HCV co-infection were assessed by logistic regression models. Factors associated with post-ART HIV immunological response (CD4 change after six months) and virological response (HIV RNA
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0150512