Impact of Bacterial and Human Genetic Variation on Staphylococcus aureus Infections

[...]genome sequencing of isolates causing invasive disease has shown considerable within-host diversity in S. aureus, including multiple mutations in the same genes [38]. [...]human genetic variation may be minimized by limiting study populations to single ethnic backgrounds when conducting human...

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Veröffentlicht in:	PLoS pathogens 2016-01, Vol.12 (1), p.e1005330-e1005330
Hauptverfasser:	Messina, Julia A, Thaden, Joshua T, Sharma-Kuinkel, Batu K, Fowler, Jr, Vance G
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteriology Funding Genes Genetic aspects Genetic variation Genetic Variation - genetics Host-bacteria relationships Humans Multiculturalism & pluralism Observations Pathogenesis Pathogens Pearls Proteins Sepsis Staphylococcal Infections - genetics Staphylococcal Infections - microbiology Staphylococcus aureus - genetics Staphylococcus aureus infections Staphylococcus infections Studies
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Zusammenfassung:	[...]genome sequencing of isolates causing invasive disease has shown considerable within-host diversity in S. aureus, including multiple mutations in the same genes [38]. [...]human genetic variation may be minimized by limiting study populations to single ethnic backgrounds when conducting human genotyping studies.
ISSN:	1553-7374 1553-7366 1553-7374
DOI:	10.1371/journal.ppat.1005330