Increased Risk of Herpes Zoster in Diabetic Patients Comorbid with Coronary Artery Disease and Microvascular Disorders: A Population-Based Study in Taiwan
We investigated the association between the risk of herpes zoster (HZ) and diabetes-related macrovascular comorbidities and microvascular disorders in diabetic patients. This retrospective study included 25,345 patients with newly identified HZ and age- and gender-matched controls retrieved from the...
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| Veröffentlicht in: | PloS one 2016-01, Vol.11 (1), p.e0146750-e0146750 |
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| creator | Ke, Chi-Chen Lai, Hui-Chin Lin, Ching-Heng Hung, Chih-Jen Chen, Der-Yuan Sheu, Wayne H-H Lui, Ping-Wing |
| description | We investigated the association between the risk of herpes zoster (HZ) and diabetes-related macrovascular comorbidities and microvascular disorders in diabetic patients. This retrospective study included 25,345 patients with newly identified HZ and age- and gender-matched controls retrieved from the National Health Insurance Research Database in Taiwan during the period of 2005 to 2011. Multivariate logistic regression analyses were used to calculate the odds ratios (OR) and to assess the risk factors for HZ in diabetic patients with associated macrovascular or microvascular disorders. Risk factors for HZ were significantly increased in cases of diabetes mellitus (DM) compared with those in cases of non-DM controls (20.2% vs. 17.0%, OR = 1.24, p |
| doi_str_mv | 10.1371/journal.pone.0146750 |
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This retrospective study included 25,345 patients with newly identified HZ and age- and gender-matched controls retrieved from the National Health Insurance Research Database in Taiwan during the period of 2005 to 2011. Multivariate logistic regression analyses were used to calculate the odds ratios (OR) and to assess the risk factors for HZ in diabetic patients with associated macrovascular or microvascular disorders. Risk factors for HZ were significantly increased in cases of diabetes mellitus (DM) compared with those in cases of non-DM controls (20.2% vs. 17.0%, OR = 1.24, p<0.001). Results of age- and gender-adjusted analyses demonstrated a significantly higher risk of HZ in DM patients with accompanying coronary artery disease (CAD) (adjusted OR = 1.21, p<0.001) and microvascular disorders (aOR = 1.32, p<0.001) than in DM patients with other comorbidities but no microvascular disorders. Patients who took thiazolidinedione, alpha-glucosidase inhibitors and insulin had a higher HZ risk than those taking metformin or sulphonylureas alone (aOR = 1.11, 1.14 and 1.18, p<0.001, respectively). Patients who took insulin alone or in combination with other antidiabetic agents had a significantly higher risk of HZ (aOR = 1.25, p<0.001) than those who received monotherapy. Diabetic patients comorbid with coronary artery disease and associated microvascular disorders had an increased risk of HZ occurrence.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0146750</identifier><identifier>PMID: 26751202</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Aged ; Anesthesiology ; Antidiabetics ; Atherosclerosis ; Cardiovascular disease ; Care and treatment ; Case-Control Studies ; Chicken pox ; Comorbidity ; Complications and side effects ; Coronary artery ; Coronary artery disease ; Coronary Artery Disease - complications ; Coronary heart disease ; Coronary vessels ; Databases, Factual ; Development and progression ; Diabetes ; Diabetes Complications - epidemiology ; Diabetes Complications - therapy ; Diabetes mellitus ; Diabetes Mellitus - drug therapy ; Disorders ; Endothelium ; Epidemiology ; Female ; Glucosidase ; Glycoside Hydrolase Inhibitors - therapeutic use ; Health insurance ; Health risk assessment ; Health risks ; Heart diseases ; Herpes zoster ; Herpes Zoster - complications ; Hospitals ; Humans ; Hypoglycemic Agents - therapeutic use ; Infections ; Inflammation ; Information retrieval ; Insulin ; Internal medicine ; Inulin - therapeutic use ; Male ; Medical research ; Metformin ; Metformin - therapeutic use ; Microcirculation ; Microvasculature ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Pathogenesis ; Patient outcomes ; Patients ; Population ; Population studies ; Population-based studies ; Regression analysis ; Retrospective Studies ; Risk analysis ; Risk Factors ; Studies ; Sulfonylurea Compounds - therapeutic use ; Taiwan - epidemiology ; Thiazolidinediones - therapeutic use ; Vascular Diseases - complications ; Young Adult ; α-Glucosidase</subject><ispartof>PloS one, 2016-01, Vol.11 (1), p.e0146750-e0146750</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Ke et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Ke et al 2016 Ke et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-2f6eca4dd0e5cce4e5fb4584752fb8f4f2f6031065fe6f6dbf69ff722f544d0b3</citedby><cites>FETCH-LOGICAL-c692t-2f6eca4dd0e5cce4e5fb4584752fb8f4f2f6031065fe6f6dbf69ff722f544d0b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709044/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709044/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26751202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ke, Chi-Chen</creatorcontrib><creatorcontrib>Lai, Hui-Chin</creatorcontrib><creatorcontrib>Lin, Ching-Heng</creatorcontrib><creatorcontrib>Hung, Chih-Jen</creatorcontrib><creatorcontrib>Chen, Der-Yuan</creatorcontrib><creatorcontrib>Sheu, Wayne H-H</creatorcontrib><creatorcontrib>Lui, Ping-Wing</creatorcontrib><title>Increased Risk of Herpes Zoster in Diabetic Patients Comorbid with Coronary Artery Disease and Microvascular Disorders: A Population-Based Study in Taiwan</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>We investigated the association between the risk of herpes zoster (HZ) and diabetes-related macrovascular comorbidities and microvascular disorders in diabetic patients. This retrospective study included 25,345 patients with newly identified HZ and age- and gender-matched controls retrieved from the National Health Insurance Research Database in Taiwan during the period of 2005 to 2011. Multivariate logistic regression analyses were used to calculate the odds ratios (OR) and to assess the risk factors for HZ in diabetic patients with associated macrovascular or microvascular disorders. Risk factors for HZ were significantly increased in cases of diabetes mellitus (DM) compared with those in cases of non-DM controls (20.2% vs. 17.0%, OR = 1.24, p<0.001). Results of age- and gender-adjusted analyses demonstrated a significantly higher risk of HZ in DM patients with accompanying coronary artery disease (CAD) (adjusted OR = 1.21, p<0.001) and microvascular disorders (aOR = 1.32, p<0.001) than in DM patients with other comorbidities but no microvascular disorders. Patients who took thiazolidinedione, alpha-glucosidase inhibitors and insulin had a higher HZ risk than those taking metformin or sulphonylureas alone (aOR = 1.11, 1.14 and 1.18, p<0.001, respectively). Patients who took insulin alone or in combination with other antidiabetic agents had a significantly higher risk of HZ (aOR = 1.25, p<0.001) than those who received monotherapy. Diabetic patients comorbid with coronary artery disease and associated microvascular disorders had an increased risk of HZ occurrence.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anesthesiology</subject><subject>Antidiabetics</subject><subject>Atherosclerosis</subject><subject>Cardiovascular disease</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Chicken pox</subject><subject>Comorbidity</subject><subject>Complications and side effects</subject><subject>Coronary artery</subject><subject>Coronary artery disease</subject><subject>Coronary Artery Disease - complications</subject><subject>Coronary heart disease</subject><subject>Coronary vessels</subject><subject>Databases, Factual</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Diabetes Complications - epidemiology</subject><subject>Diabetes Complications - therapy</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - drug therapy</subject><subject>Disorders</subject><subject>Endothelium</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Glucosidase</subject><subject>Glycoside Hydrolase Inhibitors - therapeutic use</subject><subject>Health insurance</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Heart diseases</subject><subject>Herpes zoster</subject><subject>Herpes Zoster - complications</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Information retrieval</subject><subject>Insulin</subject><subject>Internal medicine</subject><subject>Inulin - therapeutic use</subject><subject>Male</subject><subject>Medical research</subject><subject>Metformin</subject><subject>Metformin - therapeutic use</subject><subject>Microcirculation</subject><subject>Microvasculature</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Odds Ratio</subject><subject>Pathogenesis</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Population</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Regression analysis</subject><subject>Retrospective Studies</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Studies</subject><subject>Sulfonylurea Compounds - therapeutic use</subject><subject>Taiwan - epidemiology</subject><subject>Thiazolidinediones - therapeutic use</subject><subject>Vascular Diseases - complications</subject><subject>Young Adult</subject><subject>α-Glucosidase</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk99v0zAQxyMEYmPwHyCwhITgocVxbCfhAamUH6s0tGkbPPBiOfa5dZfGxU42-q_w1-Js2dSiPaA8OD5_7nu-812SPE_xOM3y9N3Sdb6R9XjtGhjjlPKc4QfJflpmZMQJzh5u_e8lT0JYYsyygvPHyR6JcEow2U_-zBrlQQbQ6NSGC-QMOgS_hoB-utCCR7ZBn6ysoLUKncjWQtMGNHUr5yur0ZVtF3HnXSP9Bk189NhEPvSKSDYafbPKu0sZVFdL3584r8GH92iCTtw6GlvrmtHH6wuctZ3e9AHPpb2SzdPkkZF1gGfDepB8__L5fHo4Ojr-OptOjkaKl6QdEcNBSao1BqYUUGCmoqygOSOmKgw1EcBZijkzwA3XleGlMTkhhlGqcZUdJC9vdNe1C2IoaxBpzlheloSkkZjdENrJpVh7u4rZCietuDY4PxfSxwLVIHLICpNVpMzzkrKKVKxkmKqMa5kWLOVR68MQratWoFWsp5f1jujuSWMXYu4uBc1xiSmNAm8GAe9-dRBasbJBQV3LBlzX35vjgmV5gSP66h_0_uwGai5jArYxLsZVvaiY0KzkGFOcR2p8DxU_DSurYg8aG-07Dm93HCLTwu92LrsQxOzs9P_Z4x-77OstdgGybhfB1V3fSGEXpDdg7MAQPJi7IqdY9CN0Ww3Rj5AYRii6vdh-oDun25nJ_gKlDRe_</recordid><startdate>20160111</startdate><enddate>20160111</enddate><creator>Ke, Chi-Chen</creator><creator>Lai, Hui-Chin</creator><creator>Lin, Ching-Heng</creator><creator>Hung, Chih-Jen</creator><creator>Chen, Der-Yuan</creator><creator>Sheu, Wayne H-H</creator><creator>Lui, Ping-Wing</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20160111</creationdate><title>Increased Risk of Herpes Zoster in Diabetic Patients Comorbid with Coronary Artery Disease and Microvascular Disorders: A Population-Based Study in Taiwan</title><author>Ke, Chi-Chen ; Lai, Hui-Chin ; Lin, Ching-Heng ; Hung, Chih-Jen ; Chen, Der-Yuan ; Sheu, Wayne H-H ; Lui, Ping-Wing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-2f6eca4dd0e5cce4e5fb4584752fb8f4f2f6031065fe6f6dbf69ff722f544d0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anesthesiology</topic><topic>Antidiabetics</topic><topic>Atherosclerosis</topic><topic>Cardiovascular disease</topic><topic>Care and treatment</topic><topic>Case-Control Studies</topic><topic>Chicken pox</topic><topic>Comorbidity</topic><topic>Complications and side effects</topic><topic>Coronary artery</topic><topic>Coronary artery disease</topic><topic>Coronary Artery Disease - complications</topic><topic>Coronary heart disease</topic><topic>Coronary vessels</topic><topic>Databases, Factual</topic><topic>Development and progression</topic><topic>Diabetes</topic><topic>Diabetes Complications - epidemiology</topic><topic>Diabetes Complications - therapy</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus - drug therapy</topic><topic>Disorders</topic><topic>Endothelium</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Glucosidase</topic><topic>Glycoside Hydrolase Inhibitors - therapeutic use</topic><topic>Health insurance</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Heart diseases</topic><topic>Herpes zoster</topic><topic>Herpes Zoster - complications</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Infections</topic><topic>Inflammation</topic><topic>Information retrieval</topic><topic>Insulin</topic><topic>Internal medicine</topic><topic>Inulin - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ke, Chi-Chen</au><au>Lai, Hui-Chin</au><au>Lin, Ching-Heng</au><au>Hung, Chih-Jen</au><au>Chen, Der-Yuan</au><au>Sheu, Wayne H-H</au><au>Lui, Ping-Wing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased Risk of Herpes Zoster in Diabetic Patients Comorbid with Coronary Artery Disease and Microvascular Disorders: A Population-Based Study in Taiwan</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-01-11</date><risdate>2016</risdate><volume>11</volume><issue>1</issue><spage>e0146750</spage><epage>e0146750</epage><pages>e0146750-e0146750</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>We investigated the association between the risk of herpes zoster (HZ) and diabetes-related macrovascular comorbidities and microvascular disorders in diabetic patients. This retrospective study included 25,345 patients with newly identified HZ and age- and gender-matched controls retrieved from the National Health Insurance Research Database in Taiwan during the period of 2005 to 2011. Multivariate logistic regression analyses were used to calculate the odds ratios (OR) and to assess the risk factors for HZ in diabetic patients with associated macrovascular or microvascular disorders. Risk factors for HZ were significantly increased in cases of diabetes mellitus (DM) compared with those in cases of non-DM controls (20.2% vs. 17.0%, OR = 1.24, p<0.001). Results of age- and gender-adjusted analyses demonstrated a significantly higher risk of HZ in DM patients with accompanying coronary artery disease (CAD) (adjusted OR = 1.21, p<0.001) and microvascular disorders (aOR = 1.32, p<0.001) than in DM patients with other comorbidities but no microvascular disorders. Patients who took thiazolidinedione, alpha-glucosidase inhibitors and insulin had a higher HZ risk than those taking metformin or sulphonylureas alone (aOR = 1.11, 1.14 and 1.18, p<0.001, respectively). Patients who took insulin alone or in combination with other antidiabetic agents had a significantly higher risk of HZ (aOR = 1.25, p<0.001) than those who received monotherapy. Diabetic patients comorbid with coronary artery disease and associated microvascular disorders had an increased risk of HZ occurrence.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26751202</pmid><doi>10.1371/journal.pone.0146750</doi><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1755799221 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adolescent Adult Aged Anesthesiology Antidiabetics Atherosclerosis Cardiovascular disease Care and treatment Case-Control Studies Chicken pox Comorbidity Complications and side effects Coronary artery Coronary artery disease Coronary Artery Disease - complications Coronary heart disease Coronary vessels Databases, Factual Development and progression Diabetes Diabetes Complications - epidemiology Diabetes Complications - therapy Diabetes mellitus Diabetes Mellitus - drug therapy Disorders Endothelium Epidemiology Female Glucosidase Glycoside Hydrolase Inhibitors - therapeutic use Health insurance Health risk assessment Health risks Heart diseases Herpes zoster Herpes Zoster - complications Hospitals Humans Hypoglycemic Agents - therapeutic use Infections Inflammation Information retrieval Insulin Internal medicine Inulin - therapeutic use Male Medical research Metformin Metformin - therapeutic use Microcirculation Microvasculature Middle Aged Multivariate Analysis Odds Ratio Pathogenesis Patient outcomes Patients Population Population studies Population-based studies Regression analysis Retrospective Studies Risk analysis Risk Factors Studies Sulfonylurea Compounds - therapeutic use Taiwan - epidemiology Thiazolidinediones - therapeutic use Vascular Diseases - complications Young Adult α-Glucosidase |
| title | Increased Risk of Herpes Zoster in Diabetic Patients Comorbid with Coronary Artery Disease and Microvascular Disorders: A Population-Based Study in Taiwan |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T14%3A43%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Increased%20Risk%20of%20Herpes%20Zoster%20in%20Diabetic%20Patients%20Comorbid%20with%20Coronary%20Artery%20Disease%20and%20Microvascular%20Disorders:%20A%20Population-Based%20Study%20in%20Taiwan&rft.jtitle=PloS%20one&rft.au=Ke,%20Chi-Chen&rft.date=2016-01-11&rft.volume=11&rft.issue=1&rft.spage=e0146750&rft.epage=e0146750&rft.pages=e0146750-e0146750&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0146750&rft_dat=%3Cgale_plos_%3EA439600407%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1755799221&rft_id=info:pmid/26751202&rft_galeid=A439600407&rft_doaj_id=oai_doaj_org_article_7e38f3b2977945b2b59504c36da18516&rfr_iscdi=true |