Increased Risk of Herpes Zoster in Diabetic Patients Comorbid with Coronary Artery Disease and Microvascular Disorders: A Population-Based Study in Taiwan

We investigated the association between the risk of herpes zoster (HZ) and diabetes-related macrovascular comorbidities and microvascular disorders in diabetic patients. This retrospective study included 25,345 patients with newly identified HZ and age- and gender-matched controls retrieved from the...

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Veröffentlicht in:	PloS one 2016-01, Vol.11 (1), p.e0146750-e0146750
Hauptverfasser:	Ke, Chi-Chen, Lai, Hui-Chin, Lin, Ching-Heng, Hung, Chih-Jen, Chen, Der-Yuan, Sheu, Wayne H-H, Lui, Ping-Wing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Anesthesiology Antidiabetics Atherosclerosis Cardiovascular disease Care and treatment Case-Control Studies Chicken pox Comorbidity Complications and side effects Coronary artery Coronary artery disease Coronary Artery Disease - complications Coronary heart disease Coronary vessels Databases, Factual Development and progression Diabetes Diabetes Complications - epidemiology Diabetes Complications - therapy Diabetes mellitus Diabetes Mellitus - drug therapy Disorders Endothelium Epidemiology Female Glucosidase Glycoside Hydrolase Inhibitors - therapeutic use Health insurance Health risk assessment Health risks Heart diseases Herpes zoster Herpes Zoster - complications Hospitals Humans Hypoglycemic Agents - therapeutic use Infections Inflammation Information retrieval Insulin Internal medicine Inulin - therapeutic use Male Medical research Metformin Metformin - therapeutic use Microcirculation Microvasculature Middle Aged Multivariate Analysis Odds Ratio Pathogenesis Patient outcomes Patients Population Population studies Population-based studies Regression analysis Retrospective Studies Risk analysis Risk Factors Studies Sulfonylurea Compounds - therapeutic use Taiwan - epidemiology Thiazolidinediones - therapeutic use Vascular Diseases - complications Young Adult α-Glucosidase
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Beschreibung
Zusammenfassung:	We investigated the association between the risk of herpes zoster (HZ) and diabetes-related macrovascular comorbidities and microvascular disorders in diabetic patients. This retrospective study included 25,345 patients with newly identified HZ and age- and gender-matched controls retrieved from the National Health Insurance Research Database in Taiwan during the period of 2005 to 2011. Multivariate logistic regression analyses were used to calculate the odds ratios (OR) and to assess the risk factors for HZ in diabetic patients with associated macrovascular or microvascular disorders. Risk factors for HZ were significantly increased in cases of diabetes mellitus (DM) compared with those in cases of non-DM controls (20.2% vs. 17.0%, OR = 1.24, p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0146750