Fatty Liver Index Associates with Relative Sarcopenia and GH/ IGF- 1 Status in Obese Subjects

Fatty Liver Index Associates with Relative Sarcopenia and GH/ IGF- 1 Status in Obese Subjects

Recently the association between hepatic steatosis and sarcopenia has been described. GH/IGF-1 axis has been postulated to play a role in linking fatty liver and low muscle mass. The aim of our study was to explore the association between fatty liver index, sarcopenic obesity, insulin sensitivity, a...

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Veröffentlicht in:PloS one 2016-01, Vol.11 (1), p.e0145811-e0145811
Hauptverfasser: Poggiogalle, Eleonora, Lubrano, Carla, Gnessi, Lucio, Mariani, Stefania, Lenzi, Andrea, Donini, Lorenzo Maria
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Analysis
Body Composition
Body composition (biology)
Body fat
Body mass
Body Mass Index
Deposition
Dual energy X-ray absorptiometry
Fatty liver
Fatty Liver - complications
Fatty Liver - genetics
Fatty Liver - metabolism
Fatty Liver - pathology
Female
Gene Expression
Ghrelin - genetics
Ghrelin - metabolism
Glucose
Growth hormone
Growth hormones
Humans
Insulin
Insulin Resistance
Insulin-like growth factor I
Insulin-Like Growth Factor I - genetics
Insulin-Like Growth Factor I - metabolism
Insulin-like growth factors
Linear Models
Liver
Liver - metabolism
Liver - pathology
Male
Middle Aged
Muscle, Skeletal - metabolism
Muscle, Skeletal - pathology
Muscles
Obesity
Obesity - complications
Obesity - genetics
Obesity - metabolism
Obesity - pathology
Physiological aspects
Regression analysis
Risk factors
Sarcopenia
Sarcopenia - complications
Sarcopenia - genetics
Sarcopenia - metabolism
Sarcopenia - pathology
Skeletal muscle
Steatosis
Womens health
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Zusammenfassung:Recently the association between hepatic steatosis and sarcopenia has been described. GH/IGF-1 axis has been postulated to play a role in linking fatty liver and low muscle mass. The aim of our study was to explore the association between fatty liver index, sarcopenic obesity, insulin sensitivity, and GH/IGF-1 status. 427 subjects [age: 45.65±13.94 years, BMI: 36.92±6.43 kg/m2] were enrolled. Participants were divided into three groups: fatty liver index (FLI)
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0145811