Incidence, Trends and Ethnic Differences of Oropharyngeal, Anal and Cervical Cancers: Singapore, 1968-2012

In recent decades, several Western countries have reported an increase in oropharyngeal and anal cancers caused by human papillomavirus (HPV). Trends in HPV-associated cancers in Asia have not been as well described. We describe the epidemiology of potentially HPV-related cancers reported to the Sin...

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Veröffentlicht in:	PloS one 2015-12, Vol.10 (12), p.e0146185-e0146185
Hauptverfasser:	Lam, Jennifer O, Lim, Wei-Yen, Chow, Khuan-Yew, D'Souza, Gypsyamber
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous polyposis coli Adult Age Aged Anal cancer Anus Neoplasms - epidemiology Anus Neoplasms - etiology Anus Neoplasms - virology Cancer Carcinoma, Squamous Cell - epidemiology Carcinoma, Squamous Cell - etiology Carcinoma, Squamous Cell - virology Cervical cancer Comparators Cultural differences Demographic aspects Distribution Epidemiology Ethnic Groups Ethnicity Female Forecasts and trends Foreign residents Gender differences Head Head & neck cancer Head and neck cancer Head and Neck Neoplasms - epidemiology Head and Neck Neoplasms - etiology Head and Neck Neoplasms - virology Health risk assessment Human papillomavirus Humans Incidence Infections Invasiveness Lung cancer Male Medical screening Medicine Men Mens health Middle Aged Minority & ethnic groups Oncology Oropharyngeal Neoplasms - epidemiology Oropharyngeal Neoplasms - etiology Oropharyngeal Neoplasms - virology Papillomaviridae Papillomavirus Infections - complications Pharyngeal cancer Population Public health Regression analysis Singapore - epidemiology Squamous cell carcinoma Tobacco Trends Uterine Cervical Neoplasms - epidemiology Uterine Cervical Neoplasms - etiology Uterine Cervical Neoplasms - virology Young Adult
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Zusammenfassung:	In recent decades, several Western countries have reported an increase in oropharyngeal and anal cancers caused by human papillomavirus (HPV). Trends in HPV-associated cancers in Asia have not been as well described. We describe the epidemiology of potentially HPV-related cancers reported to the Singapore Cancer Registry from 1968-2012. Analysis included 998 oropharyngeal squamous cell carcinoma (OPSCC), 183 anal squamous cell carcinoma (ASCC) and 8,019 invasive cervical cancer (ICC) cases. Additionally, 368 anal non-squamous cell carcinoma (ANSCC) and 2,018 non-oropharyngeal head and neck carcinoma (non-OP HNC) cases were included as comparators. Age-standardized incidence rates (ASR) were determined by gender and ethnicity (Chinese, Malay and Indian). Joinpoint regression was used to evaluate annual percentage change (APC) in incidence. OPSCC incidence increased in both genders (men 1993-2012, APC = 1.9%, p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0146185