RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression

RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression

Huntington's Disease (HD) is a devastating neurodegenerative disorder that is caused by an expanded CAG trinucleotide repeat in the Huntingtin (HTT) gene. Transcriptional dysregulation in the human HD brain has been documented but is incompletely understood. Here we present a genome-wide analys...

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Veröffentlicht in:PloS one 2015-12, Vol.10 (12), p.e0143563-e0143563
Hauptverfasser: Labadorf, Adam, Hoss, Andrew G, Lagomarsino, Valentina, Latourelle, Jeanne C, Hadzi, Tiffany C, Bregu, Joli, MacDonald, Marcy E, Gusella, James F, Chen, Jiang-Fan, Akbarian, Schahram, Weng, Zhiping, Myers, Richard H
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Bioinformatics
Brain
Brain - immunology
Brain - metabolism
Brain research
Care and treatment
Development and progression
Diagnosis
Disease
Gene expression
Gene Expression Profiling - methods
Gene Expression Regulation
Gene sequencing
Genes
Genes, Developmental
Genes, Homeobox
Genetic research
Genomes
Homeobox
Humans
Huntingtin
Huntington Disease - genetics
Huntington's disease
Huntingtons disease
Immune response
Immune system
Inflammation
Inflammation - genetics
Male
Medical schools
Medicine
Middle Aged
Mitochondria
Neurodegeneration
Neurodegenerative diseases
Neurology
Next-generation sequencing
Nucleotide sequence
Pathogenesis
Patient outcomes
Polyglutamine
Prefrontal cortex
Ribonucleic acid
RNA
Sequence Analysis, RNA - methods
Transcription
Trinucleotide repeats
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Zusammenfassung:Huntington's Disease (HD) is a devastating neurodegenerative disorder that is caused by an expanded CAG trinucleotide repeat in the Huntingtin (HTT) gene. Transcriptional dysregulation in the human HD brain has been documented but is incompletely understood. Here we present a genome-wide analysis of mRNA expression in human prefrontal cortex from 20 HD and 49 neuropathologically normal controls using next generation high-throughput sequencing. Surprisingly, 19% (5,480) of the 28,087 confidently detected genes are differentially expressed (FDR
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0143563