PharmDB-K: Integrated Bio-Pharmacological Network Database for Traditional Korean Medicine

Despite the growing attention given to Traditional Medicine (TM) worldwide, there is no well-known, publicly available, integrated bio-pharmacological Traditional Korean Medicine (TKM) database for researchers in drug discovery. In this study, we have constructed PharmDB-K, which offers comprehensiv...

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Veröffentlicht in:PloS one 2015-11, Vol.10 (11), p.e0142624-e0142624
Hauptverfasser: Lee, Ji-Hyun, Park, Kyoung Mii, Han, Dong-Jin, Bang, Nam Young, Kim, Do-Hee, Na, Hyeongjin, Lim, Semi, Kim, Tae Bum, Kim, Dae Gyu, Kim, Hyun-Jung, Chung, Yeonseok, Sung, Sang Hyun, Surh, Young-Joon, Kim, Sunghoon, Han, Byung Woo
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Sprache:eng
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Zusammenfassung:Despite the growing attention given to Traditional Medicine (TM) worldwide, there is no well-known, publicly available, integrated bio-pharmacological Traditional Korean Medicine (TKM) database for researchers in drug discovery. In this study, we have constructed PharmDB-K, which offers comprehensive information relating to TKM-associated drugs (compound), disease indication, and protein relationships. To explore the underlying molecular interaction of TKM, we integrated fourteen different databases, six Pharmacopoeias, and literature, and established a massive bio-pharmacological network for TKM and experimentally validated some cases predicted from the PharmDB-K analyses. Currently, PharmDB-K contains information about 262 TKMs, 7,815 drugs, 3,721 diseases, 32,373 proteins, and 1,887 side effects. One of the unique sets of information in PharmDB-K includes 400 indicator compounds used for standardization of herbal medicine. Furthermore, we are operating PharmDB-K via phExplorer (a network visualization software) and BioMart (a data federation framework) for convenient search and analysis of the TKM network. Database URL: http://pharmdb-k.org, http://biomart.i-pharm.org.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0142624