A Comprehensive Analysis of Common and Rare Variants to Identify Adiposity Loci in Hispanic Americans: The IRAS Family Study (IRASFS)

Obesity is growing epidemic affecting 35% of adults in the United States. Previous genome-wide association studies (GWAS) have identified numerous loci associated with obesity. However, the majority of studies have been completed in Caucasians focusing on total body measures of adiposity. Here we re...

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Veröffentlicht in:	PloS one 2015-11, Vol.10 (11), p.e0134649-e0134649
Hauptverfasser:	Gao, Chuan, Wang, Nan, Guo, Xiuqing, Ziegler, Julie T, Taylor, Kent D, Xiang, Anny H, Hai, Yang, Kridel, Steven J, Nadler, Jerry L, Kandeel, Fouad, Raffel, Leslie J, Chen, Yii-Der I, Norris, Jill M, Rotter, Jerome I, Watanabe, Richard M, Wagenknecht, Lynne E, Bowden, Donald W, Speliotes, Elizabeth K, Goodarzi, Mark O, Langefeld, Carl D, Palmer, Nicholette D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Adiposity - genetics Adults Analysis Animal models Arteriosclerosis Atherosclerosis Biochemistry Bioinformatics Biomedical research Biophysics Biosynthesis Body fat Body mass Body mass index Body size Cancer Cardiovascular disease Cell culture Cholesterol Dehydrogenases Diabetes Epidemics Family studies Gene expression Genetic aspects Genetic Association Studies Genetic Predisposition to Disease Genomes Genomics Health care Hip Hispanic Americans Hispanic Americans - genetics Hispanic people Humans Insulin Internal medicine Isocitrate dehydrogenase Isocitrate Dehydrogenase - genetics Loci Membrane Proteins - genetics Meta-analysis Metabolic disorders Mutation Obesity Obesity - genetics Pediatrics Physiological aspects Physiology Polymorphism, Single Nucleotide Population Preventive medicine Public health Replication Single nucleotide polymorphisms Single-nucleotide polymorphism Zinc Zinc finger proteins
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Zusammenfassung:	Obesity is growing epidemic affecting 35% of adults in the United States. Previous genome-wide association studies (GWAS) have identified numerous loci associated with obesity. However, the majority of studies have been completed in Caucasians focusing on total body measures of adiposity. Here we report the results from genome-wide and exome chip association studies focusing on total body measures of adiposity including body mass index (BMI), percent body fat (PBF) and measures of fat deposition including waist circumference (WAIST), waist-hip ratio (WHR), subcutaneous adipose tissue (SAT), and visceral adipose tissue (VAT) in Hispanic Americans (nmax = 1263) from the Insulin Resistance Atherosclerosis Family Study (IRASFS). Five SNPs from two novel loci attained genome-wide significance (P
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0134649