Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells

Statins are widely used in the treatment of hypercholesterolemia and are efficient in the prevention of cardiovascular disease. Molecular mechanisms explaining statin-induced impairment in insulin secretion remain largely unknown. In the current study, we show that simvastatin decreased glucose-stim...

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Veröffentlicht in:	PloS one 2015-11, Vol.10 (11), p.e0142902-e0142902
Hauptverfasser:	Yaluri, Nagendra, Modi, Shalem, López Rodríguez, Maykel, Stančáková, Alena, Kuusisto, Johanna, Kokkola, Tarja, Laakso, Markku
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors (muscarinic) Adenosine Triphosphate - chemistry Animals Calcium Calcium (reticular) Calcium - metabolism Calcium channels Calcium channels (voltage-gated) Cardiovascular diseases Cell Line Channels Colforsin - metabolism Complications and side effects Cyclic AMP - metabolism Diabetes mellitus Diabetes Mellitus - metabolism Diabetes research Disease susceptibility Endoplasmic reticulum Erythrocyte Membrane - metabolism Fatty Acids - metabolism Forskolin Glucagon-Like Peptide-1 Receptor - metabolism Glucose Glucose - metabolism Health aspects Health risks Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Hypercholesterolemia Hyperglycemia Insulin Insulin - metabolism Insulin Secretion Kinases Male Metabolic Syndrome - blood Mice Middle Aged Molecular modelling Pancreas Pancreas - drug effects Potassium Potassium channels Potassium channels (voltage-gated) Pravastatin Pravastatin - pharmacology Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - metabolism Risk Factors Rodents Secretion Signal Transduction Simvastatin Simvastatin - adverse effects Simvastatin - pharmacology Statins
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Zusammenfassung:	Statins are widely used in the treatment of hypercholesterolemia and are efficient in the prevention of cardiovascular disease. Molecular mechanisms explaining statin-induced impairment in insulin secretion remain largely unknown. In the current study, we show that simvastatin decreased glucose-stimulated insulin secretion in mouse pancreatic MIN6 β-cells by 59% and 79% (p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0142902