Evidence for a Cystic Fibrosis Enteropathy

Previous studies have suggested the existence of enteropathy in cystic fibrosis (CF), which may contribute to intestinal function impairment, a poor nutritional status and decline in lung function. This study evaluated enterocyte damage and intestinal inflammation in CF and studied its associations...

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Veröffentlicht in:	PloS one 2015-10, Vol.10 (10), p.e0138062
Hauptverfasser:	Adriaanse, Marlou P M, van der Sande, Linda J T M, van den Neucker, Anita M, Menheere, Paul P C A, Dompeling, Edward, Buurman, Wim A, Vreugdenhil, Anita C E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Adults Aged Aged, 80 and over Care and treatment Celiac disease Child Child, Preschool Children Correlation Critical care Cystic fibrosis Cystic Fibrosis - complications Cystic Fibrosis - metabolism Cystic Fibrosis - pathology Damage assessment Development and progression Diabetes Diabetes mellitus Fatty acid-binding protein Fatty Acid-Binding Proteins - blood Fatty acids Feces - chemistry Female Gastroenterology Humans Infant Inflammation Inflammation - complications Inflammation - metabolism Inflammation - pathology Intestinal Diseases - complications Intestinal Diseases - metabolism Intestinal Diseases - pathology Intestine Leukocyte L1 Antigen Complex - analysis Life assessment Lung diseases Lungs Male Medical screening Middle Aged Mutation Neurosciences Neutrophils Nutrition Nutritional Status Pancreas Patients Pediatrics Predictive control Protein binding Proteins Proton pump inhibitors Pseudomonas aeruginosa Respiratory function Risk factors Sputum Toxicology Young Adult
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Zusammenfassung:	Previous studies have suggested the existence of enteropathy in cystic fibrosis (CF), which may contribute to intestinal function impairment, a poor nutritional status and decline in lung function. This study evaluated enterocyte damage and intestinal inflammation in CF and studied its associations with nutritional status, CF-related morbidities such as impaired lung function and diabetes, and medication use. Sixty-eight CF patients and 107 controls were studied. Levels of serum intestinal-fatty acid binding protein (I-FABP), a specific marker for enterocyte damage, were retrospectively determined. The faecal intestinal inflammation marker calprotectin was prospectively studied. Nutritional status, lung function (FEV1), exocrine pancreatic insufficiency (EPI), CF-related diabetes (CFRD) and use of proton pump inhibitors (PPI) were obtained from the medical charts. Serum I-FABP levels were elevated in CF patients as compared with controls (p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0138062