The Usefulness of Defining Rapid Virological Response by a Very Sensitive Assay (TMA) during Treatment of HCV Genotype 2/3 Infection

The aim of this study was to determine in patients with HCV genotype 2 or 3 the performance at week 4 of two assays with different sensitivities for HCV RNA detection, for the prediction of SVR and stratification for treatment duration (14 and 24 weeks). Recruitment was from two trials comparing 14...

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Veröffentlicht in:	PloS one 2015-08, Vol.10 (8), p.e0120866-e0120866
Hauptverfasser:	Dalgard, Olav, Martinot-Peignoux, Michelle, Verbaan, Hans, Bjøro, Kristian, Ring-Larsen, Helmer, Marcellin, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antiviral Agents - administration & dosage Antiviral Agents - pharmacology Antiviral drugs Assaying Clinical Medicine Clinical trials Clinical Trials as Topic Drug Therapy, Combination Female Gastroenterologi Gastroenterology and Hepatology Genotype & phenotype Genotypes Hepacivirus - drug effects Hepacivirus - genetics Hepatitis Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - virology Hepatology Humans Infections Interferon Interferon-alpha - administration & dosage Interferon-alpha - pharmacology Klinisk medicin Male Medical and Health Sciences Medicin och hälsovetenskap Middle Aged Patients Prospective Studies Recurrence Ribavirin Ribavirin - administration & dosage Ribavirin - pharmacology Ribonucleic acid RNA RNA, Viral - drug effects Sensitivity Sensitivity and Specificity Tempering Treatment Outcome Young Adult
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Beschreibung
Zusammenfassung:	The aim of this study was to determine in patients with HCV genotype 2 or 3 the performance at week 4 of two assays with different sensitivities for HCV RNA detection, for the prediction of SVR and stratification for treatment duration (14 and 24 weeks). Recruitment was from two trials comparing 14 and 24 weeks treatment to patients with rapid virological response (RVR) (n = 550). RVR was originally defined as HCV RNA
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0120866