Variable Expression of Neural Cell Adhesion Molecule Isoforms in Renal Tissue: Possible Role in Incipient Renal Fibrosis

Rare neural cell adhesion molecule (NCAM) positive cells have been previously described within the normal human adult kidney interstitium, speculating that they could increase in the interstitium with incipient interstitial renal fibrosis (IRF). In the present study, among 93 biopsy samples of vario...

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Veröffentlicht in:	PloS one 2015-09, Vol.10 (9), p.e0137028-e0137028
Hauptverfasser:	Marković-Lipkovski, Jasmina, Životić, Maja, Müller, Claudia A, Tampe, Björn, Ćirović, Sanja, Vještica, Jelena, Tomanović, Nada, Zeisberg, Michael, Müller, Gerhard A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Biopsy Care and treatment Cell adhesion Cell adhesion & migration Cell adhesion molecules Development and progression Epididymis Extracellular matrix Fibroblast growth factor receptor 1 Fibroblast growth factors Fibroblasts Fibrosis Fibrosis - metabolism Gelatinase B Gene expression Genetic aspects Homeostasis Humans Immunofluorescence Integrin alpha5beta1 - metabolism Interstitial cells Isoforms Kidney - metabolism Kidney diseases Kidney Diseases - metabolism Kidney transplantation Kidneys Kinases Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Matrix metalloproteinases Nephrology Neural cell adhesion molecule Neural Cell Adhesion Molecules - metabolism Overexpression Pathology Physiological aspects Polymerase chain reaction Protein Isoforms - metabolism Proteins Proteins - metabolism Receptor, Fibroblast Growth Factor, Type 1 - metabolism Rheumatology Risk factors RNA, Messenger - metabolism Rodents Studies Tissues Transplants & implants Tumors Up-Regulation - physiology
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Zusammenfassung:	Rare neural cell adhesion molecule (NCAM) positive cells have been previously described within the normal human adult kidney interstitium, speculating that they could increase in the interstitium with incipient interstitial renal fibrosis (IRF). In the present study, among 93 biopsy samples of various kidney diseases, NCAM+ interstitial cells were detected in 62.4% cases. An increased number of NCAM+ cells was significantly observed only in incipient IRF compared to normal renal tissues and advanced IRF stages (p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0137028