The Accumulation of VEGFA in the Glomerular Basement Membrane and Its Relationship with Podocyte Injury and Proteinuria in Alport Syndrome

The pathogenesis of proteinuria in Alport syndrome (AS) remains unclear. Vascular endothelial growth factor A (VEGFA) is a key regulator of the glomerular filtration barrier (GFB). This study explored the expression of VEGFA in the glomeruli and its accumulation in the glomerular basement membrane (...

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Veröffentlicht in:	PloS one 2015-08, Vol.10 (8), p.e0135648-e0135648
Hauptverfasser:	Wang, Haiyan, Yue, Zhihui, Wu, Jinlang, Liu, Ting, Mo, Ying, Jiang, Xiaoyun, Sun, Liangzhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Adolescent Alport syndrome Analysis Basement membranes Biomarkers - metabolism Case-Control Studies Cell adhesion & migration Child Child, Preschool Congenital diseases Electron microscopy Female Glomerular Basement Membrane - metabolism Glomerular Basement Membrane - pathology Hospitals Humans Immunofluorescence Immunoglobulins Injuries Kidney diseases Male Membrane Proteins - metabolism Microfilament Proteins - metabolism Microscopy Nephritis, Hereditary - metabolism Nephritis, Hereditary - pathology Nephritis, Hereditary - physiopathology Pathogenesis Patients Pediatrics Phosphorylation Podocytes - metabolism Podocytes - pathology Proteins Proteinuria Proteinuria - etiology Proteinuria - metabolism Rodents Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-2 - metabolism
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Zusammenfassung:	The pathogenesis of proteinuria in Alport syndrome (AS) remains unclear. Vascular endothelial growth factor A (VEGFA) is a key regulator of the glomerular filtration barrier (GFB). This study explored the expression of VEGFA in the glomeruli and its accumulation in the glomerular basement membrane (GBM) and their relationship with podocyte injury and proteinuria in Alport syndrome (AS). Clinical data and renal tissues of control patients (11 cases) and AS patients (25 cases) were included. AS patients were further divided into 2 groups according to the quantities of their urinary protein: mild to moderate proteinuria group (proteinuria
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0135648