Impact of placental Plasmodium falciparum malaria on the profile of some oxidative stress biomarkers in women living in Yaoundé, Cameroon
Impact of the pathophysiology of Plasmodium falciparum placental malaria (PM) on the profile of some oxidative stress biomarkers and their relationship with poor pregnancy outcomes in women remain unknown. Between 2013 and 2014, peripheral blood and placenta tissue from 120 Cameroonian women at deli...
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| creator | Megnekou, Rosette Djontu, Jean Claude Bigoga, Jude Daiga Medou, Fabrice Mbah Tenou, Sandrine Lissom, Abel |
| description | Impact of the pathophysiology of Plasmodium falciparum placental malaria (PM) on the profile of some oxidative stress biomarkers and their relationship with poor pregnancy outcomes in women remain unknown.
Between 2013 and 2014, peripheral blood and placenta tissue from 120 Cameroonian women at delivery were assessed for maternal haemoglobin and, parasitaemia respectively. Parasite accumulation in the placenta was investigated histologically. The levels of oxidative stress biomarkers Malondialdehyde (MDA), Nitric Oxide (NO), Superoxide dismutase (SOD), Catalase (CAT) and Gluthatione (GSH) in the supernatant of teased placenta tissues were determined by Colorimetric enzymatic assays.
Parasitaemia was inversely related to haemoglobin levels and birth weight (P |
| doi_str_mv | 10.1371/journal.pone.0134633 |
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Between 2013 and 2014, peripheral blood and placenta tissue from 120 Cameroonian women at delivery were assessed for maternal haemoglobin and, parasitaemia respectively. Parasite accumulation in the placenta was investigated histologically. The levels of oxidative stress biomarkers Malondialdehyde (MDA), Nitric Oxide (NO), Superoxide dismutase (SOD), Catalase (CAT) and Gluthatione (GSH) in the supernatant of teased placenta tissues were determined by Colorimetric enzymatic assays.
Parasitaemia was inversely related to haemoglobin levels and birth weight (P <0.001 and 0.012, respectively). The level of lipid peroxide product (MDA) was significantly higher in the malaria infected (P = 0.0047) and anaemic (P = 0.024) women compared to their non-infected and non-anaemic counterparts, respectively. A similar trend was observed with SOD levels, though not significant. The levels of MDA also correlated positively with parasitaemia (P = 0.0024) but negatively with haemoglobin levels (P = 0.002). There was no association between parasitaemia, haemoglobin level and the other oxidative stress biomarkers. From histological studies, levels of MDA associated positively and significantly with placenta malaria infection and the presence of malaria pigments. The levels of SOD, NO and CAT increased with decreasing leukocyte accumulation in the intervillous space. Baby birth weight increased significantly with SOD and CAT levels, but decreased with levels of GSH.
Placental P. falciparum infection may cause oxidative stress of the placenta tissue with MDA as a potential biomarker of PM, which alongside GSH could lead to poor pregnancy outcomes (anaemia and low birth weight). This finding contributes to the understanding of the pathophysiology of P. falciparum placental malaria in women.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0134633</identifier><identifier>PMID: 26267795</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Accumulation ; Anemia ; Antioxidants ; Biochemistry ; Biology ; Biomarkers ; Biotechnology ; Birth weight ; Cameroon ; Catalase ; Catalase - blood ; Childbirth & labor ; Colorimetry ; Female ; Glutathione - blood ; Hemoglobin ; Humans ; Infections ; Inflammation ; Leukocytes ; Lipids ; Low-birth-weight ; Malaria ; Malaria, Falciparum - blood ; Malaria, Falciparum - complications ; Malaria, Falciparum - parasitology ; Malondialdehyde ; Malondialdehyde - blood ; Nitric oxide ; Nitric Oxide - blood ; Oxidation ; Oxidative Stress ; Parasites ; Peripheral blood ; Peroxide ; Physiology ; Pigments ; Placenta ; Placenta - parasitology ; Plasmodium falciparum ; Plasmodium falciparum - isolation & purification ; Plasmodium falciparum - pathogenicity ; Pregnancy ; Pregnancy Complications, Parasitic - blood ; Pregnancy Complications, Parasitic - parasitology ; Pregnancy Outcome ; Public health ; Studies ; Superoxide dismutase ; Superoxide Dismutase - blood ; Vector-borne diseases ; Womens health</subject><ispartof>PloS one, 2015-08, Vol.10 (8), p.e0134633-e0134633</ispartof><rights>2015 Megnekou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Megnekou et al 2015 Megnekou et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c592t-108beb74b425fb697e04ee820e11a66fe5bc583a7e358fd8d1112b7bc6191413</citedby><cites>FETCH-LOGICAL-c592t-108beb74b425fb697e04ee820e11a66fe5bc583a7e358fd8d1112b7bc6191413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534041/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534041/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26267795$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Luty, Adrian J.F.</contributor><creatorcontrib>Megnekou, Rosette</creatorcontrib><creatorcontrib>Djontu, Jean Claude</creatorcontrib><creatorcontrib>Bigoga, Jude Daiga</creatorcontrib><creatorcontrib>Medou, Fabrice Mbah</creatorcontrib><creatorcontrib>Tenou, Sandrine</creatorcontrib><creatorcontrib>Lissom, Abel</creatorcontrib><title>Impact of placental Plasmodium falciparum malaria on the profile of some oxidative stress biomarkers in women living in Yaoundé, Cameroon</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Impact of the pathophysiology of Plasmodium falciparum placental malaria (PM) on the profile of some oxidative stress biomarkers and their relationship with poor pregnancy outcomes in women remain unknown.
Between 2013 and 2014, peripheral blood and placenta tissue from 120 Cameroonian women at delivery were assessed for maternal haemoglobin and, parasitaemia respectively. Parasite accumulation in the placenta was investigated histologically. The levels of oxidative stress biomarkers Malondialdehyde (MDA), Nitric Oxide (NO), Superoxide dismutase (SOD), Catalase (CAT) and Gluthatione (GSH) in the supernatant of teased placenta tissues were determined by Colorimetric enzymatic assays.
Parasitaemia was inversely related to haemoglobin levels and birth weight (P <0.001 and 0.012, respectively). The level of lipid peroxide product (MDA) was significantly higher in the malaria infected (P = 0.0047) and anaemic (P = 0.024) women compared to their non-infected and non-anaemic counterparts, respectively. A similar trend was observed with SOD levels, though not significant. The levels of MDA also correlated positively with parasitaemia (P = 0.0024) but negatively with haemoglobin levels (P = 0.002). There was no association between parasitaemia, haemoglobin level and the other oxidative stress biomarkers. From histological studies, levels of MDA associated positively and significantly with placenta malaria infection and the presence of malaria pigments. The levels of SOD, NO and CAT increased with decreasing leukocyte accumulation in the intervillous space. Baby birth weight increased significantly with SOD and CAT levels, but decreased with levels of GSH.
Placental P. falciparum infection may cause oxidative stress of the placenta tissue with MDA as a potential biomarker of PM, which alongside GSH could lead to poor pregnancy outcomes (anaemia and low birth weight). This finding contributes to the understanding of the pathophysiology of P. falciparum placental malaria in women.</description><subject>Accumulation</subject><subject>Anemia</subject><subject>Antioxidants</subject><subject>Biochemistry</subject><subject>Biology</subject><subject>Biomarkers</subject><subject>Biotechnology</subject><subject>Birth weight</subject><subject>Cameroon</subject><subject>Catalase</subject><subject>Catalase - blood</subject><subject>Childbirth & labor</subject><subject>Colorimetry</subject><subject>Female</subject><subject>Glutathione - blood</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Leukocytes</subject><subject>Lipids</subject><subject>Low-birth-weight</subject><subject>Malaria</subject><subject>Malaria, Falciparum - blood</subject><subject>Malaria, Falciparum - complications</subject><subject>Malaria, Falciparum - parasitology</subject><subject>Malondialdehyde</subject><subject>Malondialdehyde - blood</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - blood</subject><subject>Oxidation</subject><subject>Oxidative Stress</subject><subject>Parasites</subject><subject>Peripheral blood</subject><subject>Peroxide</subject><subject>Physiology</subject><subject>Pigments</subject><subject>Placenta</subject><subject>Placenta - parasitology</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium falciparum - isolation & purification</subject><subject>Plasmodium falciparum - pathogenicity</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Parasitic - blood</subject><subject>Pregnancy Complications, Parasitic - parasitology</subject><subject>Pregnancy Outcome</subject><subject>Public health</subject><subject>Studies</subject><subject>Superoxide dismutase</subject><subject>Superoxide Dismutase - blood</subject><subject>Vector-borne diseases</subject><subject>Womens health</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptUstu1DAUjRCIlsIfILDEhgUz2PEjyQYJjQqMVAkW3bCybOdm6sGxg50M8Av9E76DH8OZmVYtYuVr-5xzz706RfGc4CWhFXm7DVP0yi2H4GGJCWWC0gfFKWlouRAlpg_v1CfFk5S2GHNaC_G4OClFKaqq4afF9boflBlR6NDglAE_Koe-OJX60NqpR51yxg4q5rJXTkWrUPBovAI0xNBZBzMzhT6fP22rRrsDlMYIKSFtQ6_iN4gJWY9-ZIxHzu6s38z3rypMvv3z-w1aqR5iCP5p8Sh3S_DseJ4Vlx_OL1efFhefP65X7y8WhjfluCC41qArplnJOy2aCjADqEsMhCghOuDa8JqqCiivu7ZuCSGlrrQRpCGM0LPi5UF2cCHJ4xaTJBXOeMIpy4j1AdEGtZVDtHmMXzIoK_cPIW6kiqM1DmSlm7bkQuCyqxnjXGOjKe8ams01DTFZ692x26R7aOcFR-Xuid7_8fZKbsJOsuwE7-2-PgrE8H2CNMreJgPOKQ9h2vtmlBPKeYa--gf6_-nYAWViSClCd2uGYDkn64Yl52TJY7Iy7cXdQW5JN1GifwFM7s6p</recordid><startdate>20150812</startdate><enddate>20150812</enddate><creator>Megnekou, Rosette</creator><creator>Djontu, Jean Claude</creator><creator>Bigoga, Jude Daiga</creator><creator>Medou, Fabrice Mbah</creator><creator>Tenou, Sandrine</creator><creator>Lissom, Abel</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150812</creationdate><title>Impact of placental Plasmodium falciparum malaria on the profile of some oxidative stress biomarkers in women living in Yaoundé, Cameroon</title><author>Megnekou, Rosette ; Djontu, Jean Claude ; Bigoga, Jude Daiga ; Medou, Fabrice Mbah ; Tenou, Sandrine ; Lissom, Abel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c592t-108beb74b425fb697e04ee820e11a66fe5bc583a7e358fd8d1112b7bc6191413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Accumulation</topic><topic>Anemia</topic><topic>Antioxidants</topic><topic>Biochemistry</topic><topic>Biology</topic><topic>Biomarkers</topic><topic>Biotechnology</topic><topic>Birth weight</topic><topic>Cameroon</topic><topic>Catalase</topic><topic>Catalase - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Megnekou, Rosette</au><au>Djontu, Jean Claude</au><au>Bigoga, Jude Daiga</au><au>Medou, Fabrice Mbah</au><au>Tenou, Sandrine</au><au>Lissom, Abel</au><au>Luty, Adrian J.F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of placental Plasmodium falciparum malaria on the profile of some oxidative stress biomarkers in women living in Yaoundé, Cameroon</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-08-12</date><risdate>2015</risdate><volume>10</volume><issue>8</issue><spage>e0134633</spage><epage>e0134633</epage><pages>e0134633-e0134633</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Impact of the pathophysiology of Plasmodium falciparum placental malaria (PM) on the profile of some oxidative stress biomarkers and their relationship with poor pregnancy outcomes in women remain unknown.
Between 2013 and 2014, peripheral blood and placenta tissue from 120 Cameroonian women at delivery were assessed for maternal haemoglobin and, parasitaemia respectively. Parasite accumulation in the placenta was investigated histologically. The levels of oxidative stress biomarkers Malondialdehyde (MDA), Nitric Oxide (NO), Superoxide dismutase (SOD), Catalase (CAT) and Gluthatione (GSH) in the supernatant of teased placenta tissues were determined by Colorimetric enzymatic assays.
Parasitaemia was inversely related to haemoglobin levels and birth weight (P <0.001 and 0.012, respectively). The level of lipid peroxide product (MDA) was significantly higher in the malaria infected (P = 0.0047) and anaemic (P = 0.024) women compared to their non-infected and non-anaemic counterparts, respectively. A similar trend was observed with SOD levels, though not significant. The levels of MDA also correlated positively with parasitaemia (P = 0.0024) but negatively with haemoglobin levels (P = 0.002). There was no association between parasitaemia, haemoglobin level and the other oxidative stress biomarkers. From histological studies, levels of MDA associated positively and significantly with placenta malaria infection and the presence of malaria pigments. The levels of SOD, NO and CAT increased with decreasing leukocyte accumulation in the intervillous space. Baby birth weight increased significantly with SOD and CAT levels, but decreased with levels of GSH.
Placental P. falciparum infection may cause oxidative stress of the placenta tissue with MDA as a potential biomarker of PM, which alongside GSH could lead to poor pregnancy outcomes (anaemia and low birth weight). This finding contributes to the understanding of the pathophysiology of P. falciparum placental malaria in women.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26267795</pmid><doi>10.1371/journal.pone.0134633</doi><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Accumulation Anemia Antioxidants Biochemistry Biology Biomarkers Biotechnology Birth weight Cameroon Catalase Catalase - blood Childbirth & labor Colorimetry Female Glutathione - blood Hemoglobin Humans Infections Inflammation Leukocytes Lipids Low-birth-weight Malaria Malaria, Falciparum - blood Malaria, Falciparum - complications Malaria, Falciparum - parasitology Malondialdehyde Malondialdehyde - blood Nitric oxide Nitric Oxide - blood Oxidation Oxidative Stress Parasites Peripheral blood Peroxide Physiology Pigments Placenta Placenta - parasitology Plasmodium falciparum Plasmodium falciparum - isolation & purification Plasmodium falciparum - pathogenicity Pregnancy Pregnancy Complications, Parasitic - blood Pregnancy Complications, Parasitic - parasitology Pregnancy Outcome Public health Studies Superoxide dismutase Superoxide Dismutase - blood Vector-borne diseases Womens health |
| title | Impact of placental Plasmodium falciparum malaria on the profile of some oxidative stress biomarkers in women living in Yaoundé, Cameroon |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T18%3A44%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20placental%20Plasmodium%20falciparum%20malaria%20on%20the%20profile%20of%20some%20oxidative%20stress%20biomarkers%20in%20women%20living%20in%20Yaound%C3%A9,%20Cameroon&rft.jtitle=PloS%20one&rft.au=Megnekou,%20Rosette&rft.date=2015-08-12&rft.volume=10&rft.issue=8&rft.spage=e0134633&rft.epage=e0134633&rft.pages=e0134633-e0134633&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0134633&rft_dat=%3Cproquest_plos_%3E1704351355%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1703581534&rft_id=info:pmid/26267795&rft_doaj_id=oai_doaj_org_article_7b9d256602f84455b0cb35f93425991c&rfr_iscdi=true |