Impact of placental Plasmodium falciparum malaria on the profile of some oxidative stress biomarkers in women living in Yaoundé, Cameroon

Impact of the pathophysiology of Plasmodium falciparum placental malaria (PM) on the profile of some oxidative stress biomarkers and their relationship with poor pregnancy outcomes in women remain unknown. Between 2013 and 2014, peripheral blood and placenta tissue from 120 Cameroonian women at deli...

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Veröffentlicht in:	PloS one 2015-08, Vol.10 (8), p.e0134633-e0134633
Hauptverfasser:	Megnekou, Rosette, Djontu, Jean Claude, Bigoga, Jude Daiga, Medou, Fabrice Mbah, Tenou, Sandrine, Lissom, Abel
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Anemia Antioxidants Biochemistry Biology Biomarkers Biotechnology Birth weight Cameroon Catalase Catalase - blood Childbirth & labor Colorimetry Female Glutathione - blood Hemoglobin Humans Infections Inflammation Leukocytes Lipids Low-birth-weight Malaria Malaria, Falciparum - blood Malaria, Falciparum - complications Malaria, Falciparum - parasitology Malondialdehyde Malondialdehyde - blood Nitric oxide Nitric Oxide - blood Oxidation Oxidative Stress Parasites Peripheral blood Peroxide Physiology Pigments Placenta Placenta - parasitology Plasmodium falciparum Plasmodium falciparum - isolation & purification Plasmodium falciparum - pathogenicity Pregnancy Pregnancy Complications, Parasitic - blood Pregnancy Complications, Parasitic - parasitology Pregnancy Outcome Public health Studies Superoxide dismutase Superoxide Dismutase - blood Vector-borne diseases Womens health
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Zusammenfassung:	Impact of the pathophysiology of Plasmodium falciparum placental malaria (PM) on the profile of some oxidative stress biomarkers and their relationship with poor pregnancy outcomes in women remain unknown. Between 2013 and 2014, peripheral blood and placenta tissue from 120 Cameroonian women at delivery were assessed for maternal haemoglobin and, parasitaemia respectively. Parasite accumulation in the placenta was investigated histologically. The levels of oxidative stress biomarkers Malondialdehyde (MDA), Nitric Oxide (NO), Superoxide dismutase (SOD), Catalase (CAT) and Gluthatione (GSH) in the supernatant of teased placenta tissues were determined by Colorimetric enzymatic assays. Parasitaemia was inversely related to haemoglobin levels and birth weight (P
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0134633