Host Delivery of Favorite Meals for Intracellular Pathogens

[...]a robust continuous host nutrient supply pipeline within viable host cells is essential to meet the energy demands of intravacuolar pathogens that also face the challenge of importing across the pathogen-containing vacuole. [...]the metabolic responses observed in tissue culture may vary considerably from the in vivo environment. [...]in response to hypoxia encountered within inflammatory foci, the cells respond to it through up-regulation of the hypoxia inducible factor (HIF-1) [38,39], which activates hundreds of genes required for adaption to hypoxia, including the glucose transporter and glycolytic enzymes as well as lactate dehydrogenase [5,40].