The Curious Road from Basic Pathogen Research to Clinical Translation

  [...]when my longtime collaborator Peter Forsyth injected it into human gliomas transplanted into the brains of test immunodeficient mice, the virus grew selectively within the transplanted human brain tumors just like it does in the internal tissues of myxoma-infected rabbits! Since it is totally...

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Veröffentlicht in:PLoS pathogens 2015-06, Vol.11 (6), p.e1004997-e1004997
1. Verfasser: McFadden, Grant
Format: Artikel
Sprache:eng
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Zusammenfassung:  [...]when my longtime collaborator Peter Forsyth injected it into human gliomas transplanted into the brains of test immunodeficient mice, the virus grew selectively within the transplanted human brain tumors just like it does in the internal tissues of myxoma-infected rabbits! Since it is totally nonpathogenic for humans, this discovery has convinced us to develop myxoma virus as a new potential therapeutic for a variety of human cancers.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1004997