Target Product Profile (TPP) for Chagas Disease Point-of-Care Diagnosis and Assessment of Response to Treatment

The complexity of the equipment that is required, the need for highly trained personnel, and the need for the patient to come to the health center more than once are among some of the most pressing constraints. [...]serodiagnosis in infants born to seropositive mothers has low positive predictive value due to the passive transfer of maternal anti-T. cruzi IgGs. [...]developing new diagnostic tools that are easy to use and adapted to the needs of affected populations and to the reality of health systems based on primary health care will greatly improve the ability to control Chagas disease in the Americas [16,20].