Von Willebrand Factor, ADAMTS13 and D-Dimer Are Correlated with Different Levels of Nephropathy in Type 1 Diabetes Mellitus

We have investigated whether von Willebrand factor, ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13), and D-Dimer were associated with different levels of renal function in patients with type 1 diabetes. Patients were classified according to level of renal f...

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Veröffentlicht in:	PloS one 2015-07, Vol.10 (7), p.e0132784
Hauptverfasser:	Domingueti, Caroline Pereira, Dusse, Luci Maria S, Fóscolo, Rodrigo Bastos, Reis, Janice Sepúlveda, Annichino-Bizzacchi, Joyce Maria, Orsi, Fernanda Loureiro de Andrade, Mazetto, Bruna de Moraes, Carvalho, Maria das Graças, Gomes, Karina Braga, Fernandes, Ana Paula
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM protein ADAM Proteins - metabolism ADAMTS13 Protein Adult Analysis Atherosclerosis Biomarkers Blood platelets Cardiovascular disease Diabetes Diabetes mellitus Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - metabolism Diabetic Nephropathies - complications Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology Endocrinology Energy transfer Enzyme-linked immunosorbent assay Enzymes Ethics Excretion Female Fibrin Fibrinogen Degradation Products - metabolism Fluorescence Fluorescence resonance energy transfer Glomerular filtration rate Health risk assessment Humans Kidney diseases Laboratories Male Middle Aged Mortality Nephropathy Normal distribution Patients Pharmacy Plasma levels Renal function Thrombospondin Type 1 diabetes Von Willebrand factor von Willebrand Factor - metabolism
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Zusammenfassung:	We have investigated whether von Willebrand factor, ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13), and D-Dimer were associated with different levels of renal function in patients with type 1 diabetes. Patients were classified according to level of renal function through estimated glomerular filtration rate: ≥90 and
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0132784