Late-Onset Bloodstream Infection and Perturbed Maturation of the Gastrointestinal Microbiota in Premature Infants

Late-onset bloodstream infection (LO-BSI) is a common complication of prematurity, and lack of timely diagnosis and treatment can have life-threatening consequences. We sought to identify clinical characteristics and microbial signatures in the gastrointestinal microbiota preceding diagnosis of LO-B...

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Veröffentlicht in:	PloS one 2015-07, Vol.10 (7), p.e0132923-e0132923
Hauptverfasser:	Shaw, Alexander G, Sim, Kathleen, Randell, Paul, Cox, Michael J, McClure, Zoë E, Li, Ming-Shi, Donaldson, Hugo, Langford, Paul R, Cookson, William O C M, Moffatt, Miriam F, Kroll, J Simon
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Aerobes Anaerobes Analysis Antibiotics Babies Bacteria Birth weight Deoxyribonucleic acid Diagnosis Disease prevention DNA Feces - microbiology Female Gastrointestinal system Gastrointestinal tract Gastrointestinal Tract - microbiology Gene sequencing Genomics Gestation Health aspects Humans Infant, Newborn Infant, Premature Infants Infection Infections Infectious diseases Low birth weight Male Maturation Mechanical ventilation Medicine Microbiota Microbiota (Symbiotic organisms) Microorganisms Multivariate analysis Neonates Newborn babies Nutrition Organisms Pediatrics Physiology Premature infants Probiotics Risk analysis Risk factors Risk management RNA rRNA 16S Sepsis Sepsis - diagnosis Sepsis - microbiology Staphylococcus aureus Ventilation
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Zusammenfassung:	Late-onset bloodstream infection (LO-BSI) is a common complication of prematurity, and lack of timely diagnosis and treatment can have life-threatening consequences. We sought to identify clinical characteristics and microbial signatures in the gastrointestinal microbiota preceding diagnosis of LO-BSI in premature infants. Daily faecal samples and clinical data were collected over two years from 369 premature neonates (
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0132923