NUCB2/nesfatin-1 Is Associated with Elevated Levels of Anxiety in Anorexia Nervosa

NUCB2/nesfatin-1 is an anorexigenic hormone with elevated levels in obese and decreased levels in anorexia nervosa (AN) patients. Moreover, a role in the regulation of stress and emotions was suggested by several rodent and preliminary human studies. Since anxiety and depression are common comorbidi...

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Veröffentlicht in:PloS one 2015-07, Vol.10 (7), p.e0132058-e0132058
Hauptverfasser: Hofmann, Tobias, Ahnis, Anne, Elbelt, Ulf, Rose, Matthias, Klapp, Burghard F, Stengel, Andreas
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Ahnis, Anne
Elbelt, Ulf
Rose, Matthias
Klapp, Burghard F
Stengel, Andreas
description NUCB2/nesfatin-1 is an anorexigenic hormone with elevated levels in obese and decreased levels in anorexia nervosa (AN) patients. Moreover, a role in the regulation of stress and emotions was suggested by several rodent and preliminary human studies. Since anxiety and depression are common comorbidities in AN, we investigated the association of NUCB2/nesfatin-1 with anxiety, depression and perceived stress in AN. We analyzed circulating NUCB2/nesfatin-1 levels in 64 female inpatients diagnosed with anorexia nervosa (body mass index, BMI; mean±SD, 14.7±2.3 kg/m2). At the same time anxiety (GAD-7), depression (PHQ-9), stress (PSQ-20) and disordered eating (EDI-2) were measured psychometrically. No correlation was observed between NUCB2/nesfatin-1 and BMI (r = 0.06, p = 0.70). The study population was divided in patients with low anxiety (n = 32, GAD-7 scores, mean±SD, 7.5±3.3) and high anxiety (n = 32, 16.0±3.0, p0.05). Circulating NUCB2/nesfatin-1 levels correlated positively with perceived anxiety, whereas no association with BMI or eating disorder symptoms was observed. NUCB2/nesfatin-1 might be primarily involved in the modulation of anxiety and subsequently in the regulation of eating habits and body weight in AN.
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Moreover, a role in the regulation of stress and emotions was suggested by several rodent and preliminary human studies. Since anxiety and depression are common comorbidities in AN, we investigated the association of NUCB2/nesfatin-1 with anxiety, depression and perceived stress in AN. We analyzed circulating NUCB2/nesfatin-1 levels in 64 female inpatients diagnosed with anorexia nervosa (body mass index, BMI; mean±SD, 14.7±2.3 kg/m2). At the same time anxiety (GAD-7), depression (PHQ-9), stress (PSQ-20) and disordered eating (EDI-2) were measured psychometrically. No correlation was observed between NUCB2/nesfatin-1 and BMI (r = 0.06, p = 0.70). The study population was divided in patients with low anxiety (n = 32, GAD-7 scores, mean±SD, 7.5±3.3) and high anxiety (n = 32, 16.0±3.0, p&lt;0.001). Patients with high anxiety scores displayed 65% higher NUCB2/nesfatin-1 levels (p = 0.04). This was reflected by a positive correlation of GAD-7 and NUCB2/nesfatin-1-levels (r = 0.32, p = 0.04). Scores of PSQ-20 (73.3±14.3 vs. 48.6±17.2) and PHQ-9 (18.8±5.0 vs. 10.3±5.1) were higher in the high anxiety group (p&lt;0.001) but did not correlate with NUCB2/nesfatin-1 (p&gt;0.05). EDI-2 total score was also higher in the high anxiety group (52.3±14.1 vs. 40.2±16.0, p = 0.02), while no correlations of EDI-2-scores with plasma NUCB2/nesfatin-1 were observed (p&gt;0.05). Circulating NUCB2/nesfatin-1 levels correlated positively with perceived anxiety, whereas no association with BMI or eating disorder symptoms was observed. 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NUCB2/nesfatin-1 might be primarily involved in the modulation of anxiety and subsequently in the regulation of eating habits and body weight in AN.</description><subject>Adult</subject><subject>Analysis</subject><subject>Anorexia</subject><subject>Anorexia nervosa</subject><subject>Anorexia Nervosa - blood</subject><subject>Anorexia Nervosa - complications</subject><subject>Anorexia Nervosa - psychology</subject><subject>Anxiety</subject><subject>Anxiety - blood</subject><subject>Anxiety - complications</subject><subject>Anxiety - psychology</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Body Weight</subject><subject>Bulimia</subject><subject>Calcium-Binding Proteins - blood</subject><subject>Comorbidity</subject><subject>Correlation</subject><subject>Correlation analysis</subject><subject>Demography</subject><subject>Depression - blood</subject><subject>Depression - complications</subject><subject>Depression - psychology</subject><subject>DNA-Binding Proteins - blood</subject><subject>Eating</subject><subject>Eating disorders</subject><subject>Emotions</subject><subject>Female</subject><subject>Habits</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Laws, regulations and rules</subject><subject>Mental depression</subject><subject>Nerve Tissue Proteins - blood</subject><subject>Obesity</subject><subject>Patients</subject><subject>Population studies</subject><subject>Rodents</subject><subject>Stress</subject><subject>Stress, Psychological - blood</subject><subject>Stress, Psychological - complications</subject><subject>Stresses</subject><subject>Surveys and Questionnaires</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNktFu0zAUhiMEYmPwBggiISG4aGc7iR3fIJVqQKVqkwbj1rKdk9ZTanexU7q3x22zqUG7QL7w8fF3ftvHf5K8xWiMM4bPb13XWtmM187CGOGMoKJ8lpxinpERJSh7fhSfJK-8v0WoyEpKXyYnhOKYRtlpcn15M_1Kzi34WgZjRzid-XTivdNGBqjSPyYs04sGNvvVHDbQ-NTV6cRuDYT71NgYuha2RqaX0G6cl6-TF7VsPLzp57Pk5tvFr-mP0fzq-2w6mY805SSMFGIgGdcMY6IVV4oqxjgFWWSM4lKTSnLGC0JVjgmDnGOuOFK0IMAJUpCdJe8PuuvGedG3wwtMeVRgvGSRmB2IyslbsW7NSrb3wkkj9gnXLoRsg9ENiFqqgnKeVzVCOYoh1ioHWmCFMsJkFbW-9Kd1agWVBhta2QxEhzvWLMXCbUSe85Ly3WU-9QKtu-vAB7EyXkPTSAuu29-bYo5zhiL64R_06df11ELGBxhbu3iu3omKSU5iz0rMaaTGT1BxVLAyOnqnNjE_KPg8KIhMgG1YyM57Mft5_f_s1e8h-_GIXYJswtK7pgvGWT8E8wOoW-d9C_VjkzESO-s_dEPsrC9668eyd8cf9Fj04PXsL-7l-4E</recordid><startdate>20150710</startdate><enddate>20150710</enddate><creator>Hofmann, Tobias</creator><creator>Ahnis, Anne</creator><creator>Elbelt, Ulf</creator><creator>Rose, Matthias</creator><creator>Klapp, Burghard F</creator><creator>Stengel, Andreas</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150710</creationdate><title>NUCB2/nesfatin-1 Is Associated with Elevated Levels of Anxiety in Anorexia Nervosa</title><author>Hofmann, Tobias ; 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Moreover, a role in the regulation of stress and emotions was suggested by several rodent and preliminary human studies. Since anxiety and depression are common comorbidities in AN, we investigated the association of NUCB2/nesfatin-1 with anxiety, depression and perceived stress in AN. We analyzed circulating NUCB2/nesfatin-1 levels in 64 female inpatients diagnosed with anorexia nervosa (body mass index, BMI; mean±SD, 14.7±2.3 kg/m2). At the same time anxiety (GAD-7), depression (PHQ-9), stress (PSQ-20) and disordered eating (EDI-2) were measured psychometrically. No correlation was observed between NUCB2/nesfatin-1 and BMI (r = 0.06, p = 0.70). The study population was divided in patients with low anxiety (n = 32, GAD-7 scores, mean±SD, 7.5±3.3) and high anxiety (n = 32, 16.0±3.0, p&lt;0.001). Patients with high anxiety scores displayed 65% higher NUCB2/nesfatin-1 levels (p = 0.04). This was reflected by a positive correlation of GAD-7 and NUCB2/nesfatin-1-levels (r = 0.32, p = 0.04). Scores of PSQ-20 (73.3±14.3 vs. 48.6±17.2) and PHQ-9 (18.8±5.0 vs. 10.3±5.1) were higher in the high anxiety group (p&lt;0.001) but did not correlate with NUCB2/nesfatin-1 (p&gt;0.05). EDI-2 total score was also higher in the high anxiety group (52.3±14.1 vs. 40.2±16.0, p = 0.02), while no correlations of EDI-2-scores with plasma NUCB2/nesfatin-1 were observed (p&gt;0.05). Circulating NUCB2/nesfatin-1 levels correlated positively with perceived anxiety, whereas no association with BMI or eating disorder symptoms was observed. NUCB2/nesfatin-1 might be primarily involved in the modulation of anxiety and subsequently in the regulation of eating habits and body weight in AN.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26162003</pmid><doi>10.1371/journal.pone.0132058</doi><oa>free_for_read</oa></addata></record>
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subjects Adult
Analysis
Anorexia
Anorexia nervosa
Anorexia Nervosa - blood
Anorexia Nervosa - complications
Anorexia Nervosa - psychology
Anxiety
Anxiety - blood
Anxiety - complications
Anxiety - psychology
Body mass
Body mass index
Body size
Body Weight
Bulimia
Calcium-Binding Proteins - blood
Comorbidity
Correlation
Correlation analysis
Demography
Depression - blood
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title NUCB2/nesfatin-1 Is Associated with Elevated Levels of Anxiety in Anorexia Nervosa
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