NUCB2/nesfatin-1 Is Associated with Elevated Levels of Anxiety in Anorexia Nervosa
NUCB2/nesfatin-1 is an anorexigenic hormone with elevated levels in obese and decreased levels in anorexia nervosa (AN) patients. Moreover, a role in the regulation of stress and emotions was suggested by several rodent and preliminary human studies. Since anxiety and depression are common comorbidi...
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description | NUCB2/nesfatin-1 is an anorexigenic hormone with elevated levels in obese and decreased levels in anorexia nervosa (AN) patients. Moreover, a role in the regulation of stress and emotions was suggested by several rodent and preliminary human studies. Since anxiety and depression are common comorbidities in AN, we investigated the association of NUCB2/nesfatin-1 with anxiety, depression and perceived stress in AN.
We analyzed circulating NUCB2/nesfatin-1 levels in 64 female inpatients diagnosed with anorexia nervosa (body mass index, BMI; mean±SD, 14.7±2.3 kg/m2). At the same time anxiety (GAD-7), depression (PHQ-9), stress (PSQ-20) and disordered eating (EDI-2) were measured psychometrically.
No correlation was observed between NUCB2/nesfatin-1 and BMI (r = 0.06, p = 0.70). The study population was divided in patients with low anxiety (n = 32, GAD-7 scores, mean±SD, 7.5±3.3) and high anxiety (n = 32, 16.0±3.0, p0.05).
Circulating NUCB2/nesfatin-1 levels correlated positively with perceived anxiety, whereas no association with BMI or eating disorder symptoms was observed. NUCB2/nesfatin-1 might be primarily involved in the modulation of anxiety and subsequently in the regulation of eating habits and body weight in AN. |
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We analyzed circulating NUCB2/nesfatin-1 levels in 64 female inpatients diagnosed with anorexia nervosa (body mass index, BMI; mean±SD, 14.7±2.3 kg/m2). At the same time anxiety (GAD-7), depression (PHQ-9), stress (PSQ-20) and disordered eating (EDI-2) were measured psychometrically.
No correlation was observed between NUCB2/nesfatin-1 and BMI (r = 0.06, p = 0.70). The study population was divided in patients with low anxiety (n = 32, GAD-7 scores, mean±SD, 7.5±3.3) and high anxiety (n = 32, 16.0±3.0, p<0.001). Patients with high anxiety scores displayed 65% higher NUCB2/nesfatin-1 levels (p = 0.04). This was reflected by a positive correlation of GAD-7 and NUCB2/nesfatin-1-levels (r = 0.32, p = 0.04). Scores of PSQ-20 (73.3±14.3 vs. 48.6±17.2) and PHQ-9 (18.8±5.0 vs. 10.3±5.1) were higher in the high anxiety group (p<0.001) but did not correlate with NUCB2/nesfatin-1 (p>0.05). EDI-2 total score was also higher in the high anxiety group (52.3±14.1 vs. 40.2±16.0, p = 0.02), while no correlations of EDI-2-scores with plasma NUCB2/nesfatin-1 were observed (p>0.05).
Circulating NUCB2/nesfatin-1 levels correlated positively with perceived anxiety, whereas no association with BMI or eating disorder symptoms was observed. NUCB2/nesfatin-1 might be primarily involved in the modulation of anxiety and subsequently in the regulation of eating habits and body weight in AN.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0132058</identifier><identifier>PMID: 26162003</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Analysis ; Anorexia ; Anorexia nervosa ; Anorexia Nervosa - blood ; Anorexia Nervosa - complications ; Anorexia Nervosa - psychology ; Anxiety ; Anxiety - blood ; Anxiety - complications ; Anxiety - psychology ; Body mass ; Body mass index ; Body size ; Body Weight ; Bulimia ; Calcium-Binding Proteins - blood ; Comorbidity ; Correlation ; Correlation analysis ; Demography ; Depression - blood ; Depression - complications ; Depression - psychology ; DNA-Binding Proteins - blood ; Eating ; Eating disorders ; Emotions ; Female ; Habits ; Health aspects ; Humans ; Laws, regulations and rules ; Mental depression ; Nerve Tissue Proteins - blood ; Obesity ; Patients ; Population studies ; Rodents ; Stress ; Stress, Psychological - blood ; Stress, Psychological - complications ; Stresses ; Surveys and Questionnaires ; Young Adult</subject><ispartof>PloS one, 2015-07, Vol.10 (7), p.e0132058-e0132058</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Hofmann et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Hofmann et al 2015 Hofmann et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-b07ea79c7112cb9bb6b7796ea537618c2da979526b4127e4919b90b652e920be3</citedby><cites>FETCH-LOGICAL-c692t-b07ea79c7112cb9bb6b7796ea537618c2da979526b4127e4919b90b652e920be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498697/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498697/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26162003$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hofmann, Tobias</creatorcontrib><creatorcontrib>Ahnis, Anne</creatorcontrib><creatorcontrib>Elbelt, Ulf</creatorcontrib><creatorcontrib>Rose, Matthias</creatorcontrib><creatorcontrib>Klapp, Burghard F</creatorcontrib><creatorcontrib>Stengel, Andreas</creatorcontrib><title>NUCB2/nesfatin-1 Is Associated with Elevated Levels of Anxiety in Anorexia Nervosa</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>NUCB2/nesfatin-1 is an anorexigenic hormone with elevated levels in obese and decreased levels in anorexia nervosa (AN) patients. Moreover, a role in the regulation of stress and emotions was suggested by several rodent and preliminary human studies. Since anxiety and depression are common comorbidities in AN, we investigated the association of NUCB2/nesfatin-1 with anxiety, depression and perceived stress in AN.
We analyzed circulating NUCB2/nesfatin-1 levels in 64 female inpatients diagnosed with anorexia nervosa (body mass index, BMI; mean±SD, 14.7±2.3 kg/m2). At the same time anxiety (GAD-7), depression (PHQ-9), stress (PSQ-20) and disordered eating (EDI-2) were measured psychometrically.
No correlation was observed between NUCB2/nesfatin-1 and BMI (r = 0.06, p = 0.70). The study population was divided in patients with low anxiety (n = 32, GAD-7 scores, mean±SD, 7.5±3.3) and high anxiety (n = 32, 16.0±3.0, p<0.001). Patients with high anxiety scores displayed 65% higher NUCB2/nesfatin-1 levels (p = 0.04). This was reflected by a positive correlation of GAD-7 and NUCB2/nesfatin-1-levels (r = 0.32, p = 0.04). Scores of PSQ-20 (73.3±14.3 vs. 48.6±17.2) and PHQ-9 (18.8±5.0 vs. 10.3±5.1) were higher in the high anxiety group (p<0.001) but did not correlate with NUCB2/nesfatin-1 (p>0.05). EDI-2 total score was also higher in the high anxiety group (52.3±14.1 vs. 40.2±16.0, p = 0.02), while no correlations of EDI-2-scores with plasma NUCB2/nesfatin-1 were observed (p>0.05).
Circulating NUCB2/nesfatin-1 levels correlated positively with perceived anxiety, whereas no association with BMI or eating disorder symptoms was observed. NUCB2/nesfatin-1 might be primarily involved in the modulation of anxiety and subsequently in the regulation of eating habits and body weight in AN.</description><subject>Adult</subject><subject>Analysis</subject><subject>Anorexia</subject><subject>Anorexia nervosa</subject><subject>Anorexia Nervosa - blood</subject><subject>Anorexia Nervosa - complications</subject><subject>Anorexia Nervosa - psychology</subject><subject>Anxiety</subject><subject>Anxiety - blood</subject><subject>Anxiety - complications</subject><subject>Anxiety - psychology</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Body Weight</subject><subject>Bulimia</subject><subject>Calcium-Binding Proteins - blood</subject><subject>Comorbidity</subject><subject>Correlation</subject><subject>Correlation analysis</subject><subject>Demography</subject><subject>Depression - blood</subject><subject>Depression - complications</subject><subject>Depression - psychology</subject><subject>DNA-Binding Proteins - blood</subject><subject>Eating</subject><subject>Eating disorders</subject><subject>Emotions</subject><subject>Female</subject><subject>Habits</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Laws, regulations and rules</subject><subject>Mental depression</subject><subject>Nerve Tissue Proteins - blood</subject><subject>Obesity</subject><subject>Patients</subject><subject>Population studies</subject><subject>Rodents</subject><subject>Stress</subject><subject>Stress, Psychological - blood</subject><subject>Stress, Psychological - complications</subject><subject>Stresses</subject><subject>Surveys and Questionnaires</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNktFu0zAUhiMEYmPwBggiISG4aGc7iR3fIJVqQKVqkwbj1rKdk9ZTanexU7q3x22zqUG7QL7w8fF3ftvHf5K8xWiMM4bPb13XWtmM187CGOGMoKJ8lpxinpERJSh7fhSfJK-8v0WoyEpKXyYnhOKYRtlpcn15M_1Kzi34WgZjRzid-XTivdNGBqjSPyYs04sGNvvVHDbQ-NTV6cRuDYT71NgYuha2RqaX0G6cl6-TF7VsPLzp57Pk5tvFr-mP0fzq-2w6mY805SSMFGIgGdcMY6IVV4oqxjgFWWSM4lKTSnLGC0JVjgmDnGOuOFK0IMAJUpCdJe8PuuvGedG3wwtMeVRgvGSRmB2IyslbsW7NSrb3wkkj9gnXLoRsg9ENiFqqgnKeVzVCOYoh1ioHWmCFMsJkFbW-9Kd1agWVBhta2QxEhzvWLMXCbUSe85Ly3WU-9QKtu-vAB7EyXkPTSAuu29-bYo5zhiL64R_06df11ELGBxhbu3iu3omKSU5iz0rMaaTGT1BxVLAyOnqnNjE_KPg8KIhMgG1YyM57Mft5_f_s1e8h-_GIXYJswtK7pgvGWT8E8wOoW-d9C_VjkzESO-s_dEPsrC9668eyd8cf9Fj04PXsL-7l-4E</recordid><startdate>20150710</startdate><enddate>20150710</enddate><creator>Hofmann, Tobias</creator><creator>Ahnis, Anne</creator><creator>Elbelt, Ulf</creator><creator>Rose, Matthias</creator><creator>Klapp, Burghard F</creator><creator>Stengel, Andreas</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150710</creationdate><title>NUCB2/nesfatin-1 Is Associated with Elevated Levels of Anxiety in Anorexia Nervosa</title><author>Hofmann, Tobias ; Ahnis, Anne ; Elbelt, Ulf ; Rose, Matthias ; Klapp, Burghard F ; Stengel, Andreas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-b07ea79c7112cb9bb6b7796ea537618c2da979526b4127e4919b90b652e920be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Analysis</topic><topic>Anorexia</topic><topic>Anorexia nervosa</topic><topic>Anorexia Nervosa - blood</topic><topic>Anorexia Nervosa - complications</topic><topic>Anorexia Nervosa - psychology</topic><topic>Anxiety</topic><topic>Anxiety - blood</topic><topic>Anxiety - complications</topic><topic>Anxiety - psychology</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Body Weight</topic><topic>Bulimia</topic><topic>Calcium-Binding Proteins - blood</topic><topic>Comorbidity</topic><topic>Correlation</topic><topic>Correlation analysis</topic><topic>Demography</topic><topic>Depression - blood</topic><topic>Depression - complications</topic><topic>Depression - psychology</topic><topic>DNA-Binding Proteins - blood</topic><topic>Eating</topic><topic>Eating disorders</topic><topic>Emotions</topic><topic>Female</topic><topic>Habits</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Laws, regulations and rules</topic><topic>Mental depression</topic><topic>Nerve Tissue Proteins - blood</topic><topic>Obesity</topic><topic>Patients</topic><topic>Population studies</topic><topic>Rodents</topic><topic>Stress</topic><topic>Stress, Psychological - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hofmann, Tobias</au><au>Ahnis, Anne</au><au>Elbelt, Ulf</au><au>Rose, Matthias</au><au>Klapp, Burghard F</au><au>Stengel, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>NUCB2/nesfatin-1 Is Associated with Elevated Levels of Anxiety in Anorexia Nervosa</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-07-10</date><risdate>2015</risdate><volume>10</volume><issue>7</issue><spage>e0132058</spage><epage>e0132058</epage><pages>e0132058-e0132058</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>NUCB2/nesfatin-1 is an anorexigenic hormone with elevated levels in obese and decreased levels in anorexia nervosa (AN) patients. Moreover, a role in the regulation of stress and emotions was suggested by several rodent and preliminary human studies. Since anxiety and depression are common comorbidities in AN, we investigated the association of NUCB2/nesfatin-1 with anxiety, depression and perceived stress in AN.
We analyzed circulating NUCB2/nesfatin-1 levels in 64 female inpatients diagnosed with anorexia nervosa (body mass index, BMI; mean±SD, 14.7±2.3 kg/m2). At the same time anxiety (GAD-7), depression (PHQ-9), stress (PSQ-20) and disordered eating (EDI-2) were measured psychometrically.
No correlation was observed between NUCB2/nesfatin-1 and BMI (r = 0.06, p = 0.70). The study population was divided in patients with low anxiety (n = 32, GAD-7 scores, mean±SD, 7.5±3.3) and high anxiety (n = 32, 16.0±3.0, p<0.001). Patients with high anxiety scores displayed 65% higher NUCB2/nesfatin-1 levels (p = 0.04). This was reflected by a positive correlation of GAD-7 and NUCB2/nesfatin-1-levels (r = 0.32, p = 0.04). Scores of PSQ-20 (73.3±14.3 vs. 48.6±17.2) and PHQ-9 (18.8±5.0 vs. 10.3±5.1) were higher in the high anxiety group (p<0.001) but did not correlate with NUCB2/nesfatin-1 (p>0.05). EDI-2 total score was also higher in the high anxiety group (52.3±14.1 vs. 40.2±16.0, p = 0.02), while no correlations of EDI-2-scores with plasma NUCB2/nesfatin-1 were observed (p>0.05).
Circulating NUCB2/nesfatin-1 levels correlated positively with perceived anxiety, whereas no association with BMI or eating disorder symptoms was observed. NUCB2/nesfatin-1 might be primarily involved in the modulation of anxiety and subsequently in the regulation of eating habits and body weight in AN.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26162003</pmid><doi>10.1371/journal.pone.0132058</doi><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
subjects | Adult Analysis Anorexia Anorexia nervosa Anorexia Nervosa - blood Anorexia Nervosa - complications Anorexia Nervosa - psychology Anxiety Anxiety - blood Anxiety - complications Anxiety - psychology Body mass Body mass index Body size Body Weight Bulimia Calcium-Binding Proteins - blood Comorbidity Correlation Correlation analysis Demography Depression - blood Depression - complications Depression - psychology DNA-Binding Proteins - blood Eating Eating disorders Emotions Female Habits Health aspects Humans Laws, regulations and rules Mental depression Nerve Tissue Proteins - blood Obesity Patients Population studies Rodents Stress Stress, Psychological - blood Stress, Psychological - complications Stresses Surveys and Questionnaires Young Adult |
title | NUCB2/nesfatin-1 Is Associated with Elevated Levels of Anxiety in Anorexia Nervosa |
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