Immediate Epileptogenesis after Kainate-Induced Status Epilepticus in C57BL/6J Mice: Evidence from Long Term Continuous Video-EEG Telemetry

The C57BL/6J mouse as a model of seizure/epilepsy is challenging due to high mortality and huge variability in response to kainate. We have recently demonstrated that repeated administration of a low dose of kainate by intraperitoneal route can induce severe status epilepticus (SE) with 94% survival...

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Veröffentlicht in:	PloS one 2015-07, Vol.10 (7), p.e0131705-e0131705
Hauptverfasser:	Puttachary, Sreekanth, Sharma, Shaunik, Tse, Karen, Beamer, Edward, Sexton, Abby, Crutison, Joseph, Thippeswamy, Thimmasettappa
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Analysis Animal models Animals Anticonvulsants - pharmacology Convulsions & seizures Diazepam - pharmacology Disease Models, Animal Dose-Response Relationship, Drug EEG Electroencephalography Electroencephalography - methods Epilepsy Experiments Health aspects House mouse Implanted electrodes (biology) Injections, Intraperitoneal Kainic Acid - administration & dosage Kainic Acid - toxicity Laboratories Male Mice Mice, Inbred C57BL Monitoring, Physiologic - methods Mortality Neurodegeneration Neurotoxicity Rodents Seizing Seizures Seizures (Medicine) Severity of Illness Index Status epilepticus Status Epilepticus - chemically induced Status Epilepticus - physiopathology Status Epilepticus - prevention & control Telemetry Telemetry - methods Time Factors Video Recording - methods
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Zusammenfassung:	The C57BL/6J mouse as a model of seizure/epilepsy is challenging due to high mortality and huge variability in response to kainate. We have recently demonstrated that repeated administration of a low dose of kainate by intraperitoneal route can induce severe status epilepticus (SE) with 94% survival rate. In the present study, based on continuous video-EEG recording for 4-18 weeks from epidurally implanted electrodes on the cortex, we demonstrate that this method also induces immediate epileptogenesis (
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0131705