NK Cells of Kidney Transplant Recipients Display an Activated Phenotype that Is Influenced by Immunosuppression and Pathological Staging

To explore phenotype and function of NK cells in kidney transplant recipients, we investigated the peripheral NK cell repertoire, capacity to respond to various stimuli and impact of immunosuppressive drugs on NK cell activity in kidney transplant recipients. CD56dim NK cells of kidney transplanted...

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Veröffentlicht in:	PloS one 2015-07, Vol.10 (7), p.e0132484-e0132484
Hauptverfasser:	Hoffmann, Ulrike, Neudörfl, Christine, Daemen, Kerstin, Keil, Jana, Stevanovic-Meyer, Maja, Lehner, Frank, Haller, Hermann, Blume, Cornelia, Falk, Christine S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antigens, CD - immunology Biological response modifiers Calcineurin Calcineurin inhibitors Calcium Signaling - drug effects Calcium Signaling - immunology Calcium signalling CD16 antigen CD25 antigen Cytokines Cytokines - immunology Cytotoxicity Donors Drugs Fc receptors Female Gene expression Genetic aspects Genotype & phenotype Histocompatibility antigen HLA Humans Hypertension Immunology Immunosuppression Immunosuppressive agents Immunosuppressive Agents - administration & dosage Immunotherapy Inhibitors Interferon Interleukin 10 Interleukin 13 Interleukin 17 Interleukin 22 Kidney Transplantation Kidney transplants Killer cells Killer Cells, Natural - immunology Ligands Lymphocytes Male Medical schools Middle Aged Modulation Natural killer cells Nephrology NF-AT protein Organ transplant recipients Patients Perforin Signal transduction Stimuli Studies T cell receptors TOR protein Transcription Transplantation Tolerance - drug effects Transplants & implants Tumor necrosis factor γ-Interferon
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Zusammenfassung:	To explore phenotype and function of NK cells in kidney transplant recipients, we investigated the peripheral NK cell repertoire, capacity to respond to various stimuli and impact of immunosuppressive drugs on NK cell activity in kidney transplant recipients. CD56dim NK cells of kidney transplanted patients displayed an activated phenotype characterized by significantly decreased surface expression of CD16 (p=0.0003), CD226 (p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0132484