Nonalcoholic Hepatic Steatosis Is a Strong Predictor of High-Risk Coronary-Artery Plaques as Determined by Multidetector CT

Nonalcoholic fatty liver disease is associated with a risk of coronary artery disease (e.g., diabetes mellitus, dyslipidemia, metabolic syndrome). We evaluated whether nonalcoholic hepatic steatosis is associated with high-risk plaques as assessed by multidetector computed tomography (CT). This retr...

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Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0131138-e0131138
Hauptverfasser:	Osawa, Kazuhiro, Miyoshi, Toru, Yamauchi, Kentarou, Koyama, Yasushi, Nakamura, Kazufumi, Sato, Shuhei, Kanazawa, Susumu, Ito, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute coronary syndromes Adipose tissue Aged Angiography Biopsy Calcification Cardiovascular disease Case-Control Studies CAT scans Computed tomography Confidence intervals Coronary Angiography - methods Coronary artery Coronary artery disease Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - etiology Coronary heart disease Coronary vessels Dentistry Diabetes Diabetes mellitus Dyslipidemia Fatty liver Female Health risks Heart diseases Hepatitis Hepatology Hospitals Humans Hypertension Intra-Abdominal Fat - diagnostic imaging Life assessment Liver Liver diseases Male Medical imaging Medicine Metabolic disorders Metabolic syndrome Middle Aged Morphology Multidetector Computed Tomography - methods Multivariate Analysis Non-alcoholic Fatty Liver Disease - complications Non-alcoholic Fatty Liver Disease - diagnostic imaging Obesity Patients Pharmaceutical sciences Plaque, Atherosclerotic - diagnostic imaging Plaque, Atherosclerotic - etiology Plaques Retrospective Studies Risk analysis Risk assessment Risk Factors Spleen Steatosis University graduates
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Zusammenfassung:	Nonalcoholic fatty liver disease is associated with a risk of coronary artery disease (e.g., diabetes mellitus, dyslipidemia, metabolic syndrome). We evaluated whether nonalcoholic hepatic steatosis is associated with high-risk plaques as assessed by multidetector computed tomography (CT). This retrospective study involved 414 participants suspected of having coronary artery disease. Nonalcoholic hepatic steatosis was defined as a liver-to-spleen fat ratio of
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0131138