Negativation of Trypanosoma cruzi PCR within Six Months after Treatment of a Child with Nifurtimox
According to recent estimations, there may be as many as 1,500 T. cruzi-infected individuals living in France. The absence of a pediatric formulation increases the risk of under- or overdosing in children. [...]the current development of a dispersible 12.5-mg tablet of benznidazole for the treatme...
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| Veröffentlicht in: | PLoS neglected tropical diseases 2015-05, Vol.9 (5), p.e0003667-e0003667 |
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| container_title | PLoS neglected tropical diseases |
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| creator | Pull, Lauren Touafek, Feriel Paris, Luc Le Loup, Guillaume Brutus, Laurent Siriez, Jean-Yves |
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According to recent estimations, there may be as many as 1,500 T. cruzi-infected individuals living in France. The absence of a pediatric formulation increases the risk of under- or overdosing in children. [...]the current development of a dispersible 12.5-mg tablet of benznidazole for the treatment of congenitally infected babies is likely to improve dosing accuracy in children. |
| doi_str_mv | 10.1371/journal.pntd.0003667 |
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According to recent estimations, there may be as many as 1,500 T. cruzi-infected individuals living in France. The absence of a pediatric formulation increases the risk of under- or overdosing in children. [...]the current development of a dispersible 12.5-mg tablet of benznidazole for the treatment of congenitally infected babies is likely to improve dosing accuracy in children.</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0003667</identifier><identifier>PMID: 25951170</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Antiprotozoan agents ; Case studies ; Children & youth ; Deoxyribonucleic acid ; DNA ; Dosage and administration ; Genetic aspects ; Health aspects ; Infections ; Methods ; Noncitizens ; Parents & parenting ; Patient outcomes ; Polymerase chain reaction ; Protozoa ; Studies ; Symposium ; Trypanosoma cruzi</subject><ispartof>PLoS neglected tropical diseases, 2015-05, Vol.9 (5), p.e0003667-e0003667</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Pull et al 2015 Pull et al</rights><rights>2015 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: PCR within Six Months after Treatment of a Child with Nifurtimox. PLoS Negl Trop Dis 9(5): e0003667. doi:10.1371/journal.pntd.0003667</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c629t-20c59c19037e68b322f2f0ee2dff623b5012e65bd6495c7f1833bcfab1597c7f3</citedby><cites>FETCH-LOGICAL-c629t-20c59c19037e68b322f2f0ee2dff623b5012e65bd6495c7f1833bcfab1597c7f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423973/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423973/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25951170$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Franco-Paredes, Carlos</contributor><creatorcontrib>Pull, Lauren</creatorcontrib><creatorcontrib>Touafek, Feriel</creatorcontrib><creatorcontrib>Paris, Luc</creatorcontrib><creatorcontrib>Le Loup, Guillaume</creatorcontrib><creatorcontrib>Brutus, Laurent</creatorcontrib><creatorcontrib>Siriez, Jean-Yves</creatorcontrib><title>Negativation of Trypanosoma cruzi PCR within Six Months after Treatment of a Child with Nifurtimox</title><title>PLoS neglected tropical diseases</title><addtitle>PLoS Negl Trop Dis</addtitle><description>
According to recent estimations, there may be as many as 1,500 T. cruzi-infected individuals living in France. The absence of a pediatric formulation increases the risk of under- or overdosing in children. [...]the current development of a dispersible 12.5-mg tablet of benznidazole for the treatment of congenitally infected babies is likely to improve dosing accuracy in children.</description><subject>Antiprotozoan agents</subject><subject>Case studies</subject><subject>Children & youth</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Dosage and administration</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Infections</subject><subject>Methods</subject><subject>Noncitizens</subject><subject>Parents & parenting</subject><subject>Patient outcomes</subject><subject>Polymerase chain reaction</subject><subject>Protozoa</subject><subject>Studies</subject><subject>Symposium</subject><subject>Trypanosoma cruzi</subject><issn>1935-2735</issn><issn>1935-2727</issn><issn>1935-2735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNqFkmtrFDEUhgdRbK3-A9EBQfyyay6TTPJFKIuXQq2i9XPIZE52s8wk22Smtv56M91t2QVBQsjteU9OTt6ieInRHNMav1-HMXrdzTd-aOcIIcp5_ag4xpKyGakpe7w3PyqepbRGiEkm8NPiiOQJxjU6LpoLWOrBXecefBlseRlvN9qHFHpdmjj-ceX3xY_ytxtWzpc_3U35NfhhlUptB4iZBj304IdJqsvFynXtHVxeODvGwfXh5nnxxOouwYvdeFL8-vTxcvFldv7t89ni9HxmOJHDjCDDpMES0Rq4aCghllgEQFprOaENQ5gAZ03LK8lMbbGgtDFWN5jJOq_pSfF6G3fThaR25UkKc8E4FayimTjbEm3Qa7WJrtfxVgXt1N1GiEulc86mA1WBbS1viaCNrEiV9cZQq5kFgSqoSI71YXfb2PTQmlyDqLuDoIcn3q3UMlyrKotlPSXzbhcghqsR0qB6lwx0nfYQxpx3jRgSTOaf_S_KBcJCcD6hb7boUudXOG9DvtxMuDqtsJCCcDYlP_8HlVsLvTPBg3V5_0Dwdk-wAt1lD4RunFyTDsFqC5oYUopgHyqCkZp8e_8xavKt2vk2y17tV_NBdG9U-hdx0Oo2</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Pull, Lauren</creator><creator>Touafek, Feriel</creator><creator>Paris, Luc</creator><creator>Le Loup, Guillaume</creator><creator>Brutus, Laurent</creator><creator>Siriez, Jean-Yves</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>M7N</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150501</creationdate><title>Negativation of Trypanosoma cruzi PCR within Six Months after Treatment of a Child with Nifurtimox</title><author>Pull, Lauren ; Touafek, Feriel ; Paris, Luc ; Le Loup, Guillaume ; Brutus, Laurent ; Siriez, Jean-Yves</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c629t-20c59c19037e68b322f2f0ee2dff623b5012e65bd6495c7f1833bcfab1597c7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Antiprotozoan agents</topic><topic>Case studies</topic><topic>Children & youth</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Dosage and administration</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Infections</topic><topic>Methods</topic><topic>Noncitizens</topic><topic>Parents & parenting</topic><topic>Patient outcomes</topic><topic>Polymerase chain reaction</topic><topic>Protozoa</topic><topic>Studies</topic><topic>Symposium</topic><topic>Trypanosoma cruzi</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pull, Lauren</creatorcontrib><creatorcontrib>Touafek, Feriel</creatorcontrib><creatorcontrib>Paris, Luc</creatorcontrib><creatorcontrib>Le Loup, Guillaume</creatorcontrib><creatorcontrib>Brutus, Laurent</creatorcontrib><creatorcontrib>Siriez, Jean-Yves</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS neglected tropical diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pull, Lauren</au><au>Touafek, Feriel</au><au>Paris, Luc</au><au>Le Loup, Guillaume</au><au>Brutus, Laurent</au><au>Siriez, Jean-Yves</au><au>Franco-Paredes, Carlos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Negativation of Trypanosoma cruzi PCR within Six Months after Treatment of a Child with Nifurtimox</atitle><jtitle>PLoS neglected tropical diseases</jtitle><addtitle>PLoS Negl Trop Dis</addtitle><date>2015-05-01</date><risdate>2015</risdate><volume>9</volume><issue>5</issue><spage>e0003667</spage><epage>e0003667</epage><pages>e0003667-e0003667</pages><issn>1935-2735</issn><issn>1935-2727</issn><eissn>1935-2735</eissn><abstract>
According to recent estimations, there may be as many as 1,500 T. cruzi-infected individuals living in France. The absence of a pediatric formulation increases the risk of under- or overdosing in children. [...]the current development of a dispersible 12.5-mg tablet of benznidazole for the treatment of congenitally infected babies is likely to improve dosing accuracy in children.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25951170</pmid><doi>10.1371/journal.pntd.0003667</doi><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; PubMed Central Open Access; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Antiprotozoan agents Case studies Children & youth Deoxyribonucleic acid DNA Dosage and administration Genetic aspects Health aspects Infections Methods Noncitizens Parents & parenting Patient outcomes Polymerase chain reaction Protozoa Studies Symposium Trypanosoma cruzi |
| title | Negativation of Trypanosoma cruzi PCR within Six Months after Treatment of a Child with Nifurtimox |
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