Telomeric ORFS in Candida albicans: does mediator tail wag the yeast?

Recent analysis of Mediator functions in C. albicans have shown that this complex plays an important role in regulating many virulence-associated traits such as filamentous growth, white--opaque switching, stress responses, biofilm formation, and phagocyte interactions (Fig. 1) [10-14]. An increase in copy number of the human Mediator subunit Cdk8, which is accompanied by increased expression, is found in 70% of colorectal cancer samples and is significantly correlated with increased colon cancer--specific mortality [17].