Prion strains and amyloid polymorphism influence phenotypic variation

[...]variation in amyloid-chaperone sites of interaction is likely a major determinant of the phenotypic differences caused by prion strains. [...]one conformation being uniquely thermodynamically stable above all other combinations seems unrealistic simply in terms of probability. [...]elucidating the complex interplay of variables that affect the formation and maintenance of polymorphic structures remains a nontrivial, even crucial, task to gain a full understanding of pathological variability and the etiology of protein conformational disorders.