Candida albicans pathogenicity and epithelial immunity

Furthermore, in common with the vast majority of life-threatening systemic infections, systemic Candida infections are usually acquired through mucosal surfaces. [...]it is of paramount importance to understand how epithelial tissues detect and restrict these pathogens to mucosal surfaces. [...]the epithelial PRRs or receptors involved in the induction of pro-inflammatory responses by C. albicans remain to be elucidated. [...]PI3K signalling activates epithelial damage protection/prevention mechanisms.