The exosome component Rrp6 is required for RNA polymerase II termination at specific targets of the Nrd1-Nab3 pathway

The exosome and its nuclear specific subunit Rrp6 form a 3'-5' exonuclease complex that regulates diverse aspects of RNA biology including 3' end processing and degradation of a variety of noncoding RNAs (ncRNAs) and unstable transcripts. Known targets of the nuclear exosome include s...

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Veröffentlicht in:	PLoS genetics 2015-02, Vol.11 (2), p.e1004999-e1004999
Hauptverfasser:	Fox, Melanie J, Gao, Hongyu, Smith-Kinnaman, Whitney R, Liu, Yunlong, Mosley, Amber L
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA Helicases - genetics Exosome Multienzyme Ribonuclease Complex - genetics Exosomes - genetics Exosomes - metabolism Gene expression Gene Expression Regulation, Fungal Identification and classification Methods Nuclear Proteins - genetics Nuclear Proteins - metabolism Physiological aspects Proteins RNA Helicases - genetics RNA Polymerase II - genetics RNA polymerases RNA sequencing RNA, Untranslated - genetics RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Studies Surveillance Transcription, Genetic Transcriptome - genetics Yeast
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Beschreibung
Zusammenfassung:	The exosome and its nuclear specific subunit Rrp6 form a 3'-5' exonuclease complex that regulates diverse aspects of RNA biology including 3' end processing and degradation of a variety of noncoding RNAs (ncRNAs) and unstable transcripts. Known targets of the nuclear exosome include short (
ISSN:	1553-7404 1553-7390 1553-7404
DOI:	10.1371/journal.pgen.1004999