Association between Gastroenterological Malignancy and Diabetes Mellitus and Anti-Diabetic Therapy: A Nationwide, Population-Based Cohort Study

The relationship between diabetes mellitus (DM) and cancer incidence has been evaluated in limited kinds of cancer. The effect of anti-diabetic therapy (ADT) on carcinogenesis among diabetic patients is also unclear. Using population-based representative insurance claims data in Taiwan, 36,270 DM pa...

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Veröffentlicht in:	PloS one 2015-05, Vol.10 (5), p.e0125421
Hauptverfasser:	Lin, Chien-Ming, Huang, Hui-Ling, Chu, Fang-Ying, Fan, Hueng-Chuen, Chen, Hung-An, Chu, Der-Ming, Wu, Li-Wei, Wang, Chung-Ching, Chen, Wei-Liang, Lin, Shih-Hua, Ho, Shinn-Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis Antidiabetics Bioinformatics Biology Breast cancer Cancer Carcinogenesis Carcinogens Care and treatment Cell cycle Cohort analysis Cohort Studies Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - epidemiology Colorectal Neoplasms - etiology Complications and side effects Development and progression Diabetes Diabetes mellitus Diabetes Mellitus - drug therapy Diabetes Mellitus - epidemiology Female Gender Glucosidase Glycoside Hydrolase Inhibitors - adverse effects Health insurance Health risk assessment Health risks Hospitals Humans Hyperglycemia Hypoglycemic Agents - adverse effects Incidence Inhibitors Insulin Insulin, Long-Acting - adverse effects Liver Liver cancer Liver Neoplasms - epidemiology Liver Neoplasms - etiology Lung cancer Male Malignancy Medicine Metformin Metformin - adverse effects Middle Aged Obesity Oral cancer Pancreas Pancreatic cancer Pancreatic Neoplasms - epidemiology Pancreatic Neoplasms - etiology Patients Pediatrics Population Population studies Population-based studies Retrospective Studies Review boards Risk Risk reduction Studies Systematic review Taiwan Therapy Young Adult α-Glucosidase
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Zusammenfassung:	The relationship between diabetes mellitus (DM) and cancer incidence has been evaluated in limited kinds of cancer. The effect of anti-diabetic therapy (ADT) on carcinogenesis among diabetic patients is also unclear. Using population-based representative insurance claims data in Taiwan, 36,270 DM patients and 145,080 comparison subjects without DM were identified from claims from 2005 to 2010. The association between the top ten leading causes of cancer-related death in Taiwan and DM was evaluated. Whether ADT altered the risk of developing cancer was also investigated. Incidence of cancer at any site was significantly higher in patients with DM than in those without (p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0125421