The expression of CD30 based on immunohistochemistry predicts inferior outcome in patients with diffuse large B-cell lymphoma

The prognostic value of CD30 expression in diffuse large B-cell lymphoma (DLBCL)remains controversial. Herein, we performed this retrospective study to investigate the clinical and prognostic significance of CD30 expression in patients with DLBCL.Among all the 146 patients, the expression of CD30 wa...

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Veröffentlicht in:	PloS one 2015-05, Vol.10 (5), p.e0126615-e0126615
Hauptverfasser:	Hao, Xiaoxiao, Wei, Xiaolei, Huang, Fen, Wei, Yongqiang, Zeng, Hong, Xu, Linwei, Zhou, Qinjun, Feng, Ru
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Analysis Antineoplastic Combined Chemotherapy Protocols - therapeutic use B cells B-cell lymphoma B-Lymphocytes - metabolism Bcl-2 protein Bone marrow Cancer therapies Care and treatment CD30 antigen Chemotherapy Complications and side effects Cyclophosphamide Cyclophosphamide - administration & dosage Cyclophosphamide - therapeutic use Disease-Free Survival Doxorubicin Doxorubicin - administration & dosage Doxorubicin - therapeutic use Female Gene expression Hematology Humans Immunohistochemistry Kaplan-Meier Estimate Ki-1 Antigen - immunology Ki-1 Antigen - metabolism Ki-67 Antigen - metabolism Leukemia Lymphocytes B Lymphoma Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - mortality Lymphoma, Large B-Cell, Diffuse - pathology Male Medical prognosis Medical research Medicine, Experimental Middle Aged Monoclonal antibodies Multivariate Analysis Non-Hodgkin's lymphomas Oncology Patient outcomes Patients Prednisone Prednisone - administration & dosage Prednisone - therapeutic use Prognosis Proto-Oncogene Proteins c-bcl-2 - metabolism Retrospective Studies Rituximab Rituximab - administration & dosage Studies Targeted cancer therapy Treatment Outcome Vincristine Vincristine - administration & dosage Vincristine - therapeutic use Young Adult
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Zusammenfassung:	The prognostic value of CD30 expression in diffuse large B-cell lymphoma (DLBCL)remains controversial. Herein, we performed this retrospective study to investigate the clinical and prognostic significance of CD30 expression in patients with DLBCL.Among all the 146 patients, the expression of CD30 was observed in 23 cases (15.7%).The DLBCL patients with CD30 expression showed more likely to present B symptoms, bone marrow involvement, non-germinal centre B-cell-like (Non-GCB) DLBCL, BCL-2 and Ki-67 overexpression (p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0126615