Failure of intravenous or intracardiac delivery of mesenchymal stromal cells to improve outcomes after focal traumatic brain injury in the female rat
Mesenchymal stromal cells secrete a variety of anti-inflammatory factors and may provide a regenerative medicine option for the treatment of traumatic brain injury. The present study investigates the efficacy of multiple intravenous or intracardiac administrations of rat mesenchymal stromal cells or...
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| Veröffentlicht in: | PloS one 2015-05, Vol.10 (5), p.e0126551-e0126551 |
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| creator | Turtzo, L Christine Budde, Matthew D Dean, Dana D Gold, Eric M Lewis, Bobbi K Janes, Lindsay Lescher, Jacob Coppola, Tiziana Yarnell, Angela Grunberg, Neil E Frank, Joseph A |
| description | Mesenchymal stromal cells secrete a variety of anti-inflammatory factors and may provide a regenerative medicine option for the treatment of traumatic brain injury. The present study investigates the efficacy of multiple intravenous or intracardiac administrations of rat mesenchymal stromal cells or human mesenchymal stromal cells in female rats after controlled cortical impact by in vivo MRI, neurobehavior, and histopathology evaluation. Neither intravenous nor intracardiac administration of mesenchymal stromal cells derived from either rats or humans improved MRI measures of lesion volume or neurobehavioral outcome compared to saline treatment. Few mesenchymal stromal cells ( |
| doi_str_mv | 10.1371/journal.pone.0126551 |
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The present study investigates the efficacy of multiple intravenous or intracardiac administrations of rat mesenchymal stromal cells or human mesenchymal stromal cells in female rats after controlled cortical impact by in vivo MRI, neurobehavior, and histopathology evaluation. Neither intravenous nor intracardiac administration of mesenchymal stromal cells derived from either rats or humans improved MRI measures of lesion volume or neurobehavioral outcome compared to saline treatment. Few mesenchymal stromal cells (<0.0005% of injected dose) were found within 3 days of last dosage at the site of injury after either delivery route, with no mesenchymal stromal cells being detectable in brain at 30 or 56 days post-injury. These findings suggest that non-autologous mesenchymal stromal cells therapy via intravenous or intracardiac administration is not a promising treatment after focal contusion traumatic brain injury in this female rodent model.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0126551</identifier><identifier>PMID: 25946089</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Administration, Intravenous ; Analgesics ; Animals ; Bone marrow ; Brain ; Brain - cytology ; Brain - pathology ; Brain injuries ; Brain Injuries - therapy ; Brain research ; Cardiac Catheters ; Care and treatment ; Cell- and Tissue-Based Therapy - methods ; Cells, Cultured ; Clinical psychology ; Cortex ; Diagnosis ; Disease Models, Animal ; Drug dosages ; Female ; Gender ; Head injuries ; Health sciences ; Histopathology ; Humans ; Image Processing, Computer-Assisted ; Inflammation ; Intravenous administration ; Laboratory animals ; Magnetic Resonance Imaging ; Medical care ; Medicine ; Mesenchymal Stem Cell Transplantation - methods ; Mesenchymal stem cells ; Mesenchymal Stromal Cells - cytology ; Mesenchyme ; Neurosciences ; Neurosurgery ; Patient outcomes ; Rats ; Rats, Wistar ; Regenerative medicine ; Rodents ; Stem cells ; Stromal cells ; Studies ; Systematic review ; Transplants & implants ; Traumatic brain injury ; Treatment Failure ; United States</subject><ispartof>PloS one, 2015-05, Vol.10 (5), p.e0126551-e0126551</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”) Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-3fcdfdb025ff689dbff0fd1c077e675ae57b3711ce4d76ddb9db5b17dcd20f273</citedby><cites>FETCH-LOGICAL-c758t-3fcdfdb025ff689dbff0fd1c077e675ae57b3711ce4d76ddb9db5b17dcd20f273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422703/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422703/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25946089$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Rameshwar, Pranela</contributor><creatorcontrib>Turtzo, L Christine</creatorcontrib><creatorcontrib>Budde, Matthew D</creatorcontrib><creatorcontrib>Dean, Dana D</creatorcontrib><creatorcontrib>Gold, Eric M</creatorcontrib><creatorcontrib>Lewis, Bobbi K</creatorcontrib><creatorcontrib>Janes, Lindsay</creatorcontrib><creatorcontrib>Lescher, Jacob</creatorcontrib><creatorcontrib>Coppola, Tiziana</creatorcontrib><creatorcontrib>Yarnell, Angela</creatorcontrib><creatorcontrib>Grunberg, Neil E</creatorcontrib><creatorcontrib>Frank, Joseph A</creatorcontrib><title>Failure of intravenous or intracardiac delivery of mesenchymal stromal cells to improve outcomes after focal traumatic brain injury in the female rat</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Mesenchymal stromal cells secrete a variety of anti-inflammatory factors and may provide a regenerative medicine option for the treatment of traumatic brain injury. The present study investigates the efficacy of multiple intravenous or intracardiac administrations of rat mesenchymal stromal cells or human mesenchymal stromal cells in female rats after controlled cortical impact by in vivo MRI, neurobehavior, and histopathology evaluation. Neither intravenous nor intracardiac administration of mesenchymal stromal cells derived from either rats or humans improved MRI measures of lesion volume or neurobehavioral outcome compared to saline treatment. Few mesenchymal stromal cells (<0.0005% of injected dose) were found within 3 days of last dosage at the site of injury after either delivery route, with no mesenchymal stromal cells being detectable in brain at 30 or 56 days post-injury. These findings suggest that non-autologous mesenchymal stromal cells therapy via intravenous or intracardiac administration is not a promising treatment after focal contusion traumatic brain injury in this female rodent model.</description><subject>Administration, Intravenous</subject><subject>Analgesics</subject><subject>Animals</subject><subject>Bone marrow</subject><subject>Brain</subject><subject>Brain - cytology</subject><subject>Brain - pathology</subject><subject>Brain injuries</subject><subject>Brain Injuries - therapy</subject><subject>Brain research</subject><subject>Cardiac Catheters</subject><subject>Care and treatment</subject><subject>Cell- and Tissue-Based Therapy - methods</subject><subject>Cells, Cultured</subject><subject>Clinical psychology</subject><subject>Cortex</subject><subject>Diagnosis</subject><subject>Disease Models, Animal</subject><subject>Drug dosages</subject><subject>Female</subject><subject>Gender</subject><subject>Head 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of intravenous or intracardiac delivery of mesenchymal stromal cells to improve outcomes after focal traumatic brain injury in the female rat</title><author>Turtzo, L Christine ; Budde, Matthew D ; Dean, Dana D ; Gold, Eric M ; Lewis, Bobbi K ; Janes, Lindsay ; Lescher, Jacob ; Coppola, Tiziana ; Yarnell, Angela ; Grunberg, Neil E ; Frank, Joseph A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-3fcdfdb025ff689dbff0fd1c077e675ae57b3711ce4d76ddb9db5b17dcd20f273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Administration, Intravenous</topic><topic>Analgesics</topic><topic>Animals</topic><topic>Bone marrow</topic><topic>Brain</topic><topic>Brain - cytology</topic><topic>Brain - pathology</topic><topic>Brain injuries</topic><topic>Brain Injuries - therapy</topic><topic>Brain research</topic><topic>Cardiac Catheters</topic><topic>Care and 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The present study investigates the efficacy of multiple intravenous or intracardiac administrations of rat mesenchymal stromal cells or human mesenchymal stromal cells in female rats after controlled cortical impact by in vivo MRI, neurobehavior, and histopathology evaluation. Neither intravenous nor intracardiac administration of mesenchymal stromal cells derived from either rats or humans improved MRI measures of lesion volume or neurobehavioral outcome compared to saline treatment. Few mesenchymal stromal cells (<0.0005% of injected dose) were found within 3 days of last dosage at the site of injury after either delivery route, with no mesenchymal stromal cells being detectable in brain at 30 or 56 days post-injury. These findings suggest that non-autologous mesenchymal stromal cells therapy via intravenous or intracardiac administration is not a promising treatment after focal contusion traumatic brain injury in this female rodent model.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25946089</pmid><doi>10.1371/journal.pone.0126551</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Administration, Intravenous Analgesics Animals Bone marrow Brain Brain - cytology Brain - pathology Brain injuries Brain Injuries - therapy Brain research Cardiac Catheters Care and treatment Cell- and Tissue-Based Therapy - methods Cells, Cultured Clinical psychology Cortex Diagnosis Disease Models, Animal Drug dosages Female Gender Head injuries Health sciences Histopathology Humans Image Processing, Computer-Assisted Inflammation Intravenous administration Laboratory animals Magnetic Resonance Imaging Medical care Medicine Mesenchymal Stem Cell Transplantation - methods Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchyme Neurosciences Neurosurgery Patient outcomes Rats Rats, Wistar Regenerative medicine Rodents Stem cells Stromal cells Studies Systematic review Transplants & implants Traumatic brain injury Treatment Failure United States |
| title | Failure of intravenous or intracardiac delivery of mesenchymal stromal cells to improve outcomes after focal traumatic brain injury in the female rat |
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