Failure of intravenous or intracardiac delivery of mesenchymal stromal cells to improve outcomes after focal traumatic brain injury in the female rat

Mesenchymal stromal cells secrete a variety of anti-inflammatory factors and may provide a regenerative medicine option for the treatment of traumatic brain injury. The present study investigates the efficacy of multiple intravenous or intracardiac administrations of rat mesenchymal stromal cells or...

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Veröffentlicht in:	PloS one 2015-05, Vol.10 (5), p.e0126551-e0126551
Hauptverfasser:	Turtzo, L Christine, Budde, Matthew D, Dean, Dana D, Gold, Eric M, Lewis, Bobbi K, Janes, Lindsay, Lescher, Jacob, Coppola, Tiziana, Yarnell, Angela, Grunberg, Neil E, Frank, Joseph A
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravenous Analgesics Animals Bone marrow Brain Brain - cytology Brain - pathology Brain injuries Brain Injuries - therapy Brain research Cardiac Catheters Care and treatment Cell- and Tissue-Based Therapy - methods Cells, Cultured Clinical psychology Cortex Diagnosis Disease Models, Animal Drug dosages Female Gender Head injuries Health sciences Histopathology Humans Image Processing, Computer-Assisted Inflammation Intravenous administration Laboratory animals Magnetic Resonance Imaging Medical care Medicine Mesenchymal Stem Cell Transplantation - methods Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchyme Neurosciences Neurosurgery Patient outcomes Rats Rats, Wistar Regenerative medicine Rodents Stem cells Stromal cells Studies Systematic review Transplants & implants Traumatic brain injury Treatment Failure United States
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Zusammenfassung:	Mesenchymal stromal cells secrete a variety of anti-inflammatory factors and may provide a regenerative medicine option for the treatment of traumatic brain injury. The present study investigates the efficacy of multiple intravenous or intracardiac administrations of rat mesenchymal stromal cells or human mesenchymal stromal cells in female rats after controlled cortical impact by in vivo MRI, neurobehavior, and histopathology evaluation. Neither intravenous nor intracardiac administration of mesenchymal stromal cells derived from either rats or humans improved MRI measures of lesion volume or neurobehavioral outcome compared to saline treatment. Few mesenchymal stromal cells (
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0126551