mTORC1 Regulates Flagellin-Induced Inflammatory Response in Macrophages

Bacterial flagellin triggers inflammatory responses. Phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) regulate the production of pro- and anti-inflammatory cytokines that are induced by extrinsic antigens, but the function of mTORC1 in flagellin-induced inflammatory response...

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Veröffentlicht in:	PloS one 2015-05, Vol.10 (5), p.e0125910-e0125910
Hauptverfasser:	Bao, Wenlei, Wang, Yanfeng, Fu, Yuting, Jia, Xiaoyang, Li, Jiaxin, Vangan, Nyamtsengel, Bao, Lili, Hao, Huifang, Wang, Zhigang
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animals Antigens Apoptosis Bacteria Bacterial proteins Biodegradation Cancer Cell activation Cell culture Cell growth Cell Line Cell proliferation Cell Proliferation - drug effects Cell Survival Cellular control mechanisms Cellular signal transduction Chromones - pharmacology Cytokines Cytokines - metabolism Dose-Response Relationship, Drug Flagellin Flagellin - metabolism Flagellin - pharmacology Gene expression Gene Expression Regulation Health aspects Immune response Immune system Immunoglobulins Inflammation Inflammation - genetics Inflammation - immunology Inflammation - metabolism Inflammatory response Innate immunity Interleukin 6 Kinases Life sciences Macrophages Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - immunology Macrophages, Peritoneal - metabolism Mammals MAP Kinase Signaling System - drug effects Mechanistic Target of Rapamycin Complex 1 Metabolism Mice Morpholines - pharmacology Multiprotein Complexes - metabolism NF-kappa B - metabolism NF-κB protein Pattern recognition Penicillin Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphorylation Proteins Proto-Oncogene Proteins c-akt - metabolism Rapamycin Signal Transduction - drug effects Stat3 protein STAT3 Transcription Factor - metabolism TLR5 protein Toll-Like Receptor 5 - antagonists & inhibitors Toll-Like Receptor 5 - metabolism Toll-like receptors TOR protein TOR Serine-Threonine Kinases - metabolism Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α Viral infections Wortmannin
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Zusammenfassung:	Bacterial flagellin triggers inflammatory responses. Phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) regulate the production of pro- and anti-inflammatory cytokines that are induced by extrinsic antigens, but the function of mTORC1 in flagellin-induced inflammatory response is unknown. The purpose of this study was to examine the role and the mechanism of PI3K/Akt/mTOR pathway in flagellin-induced cytokine expression in mouse macrophages. We observed that flagellin upregulated TNF-α time- and dose-dependently. Flagellin stimulated rapid (
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0125910