HIV Malaria Co-Infection Is Associated with Atypical Memory B Cell Expansion and a Reduced Antibody Response to a Broad Array of Plasmodium falciparum Antigens in Rwandan Adults

HIV infected individuals in malaria endemic areas experience more frequent and severe malaria episodes compared to non HIV infected. This clinical observation has been linked to a deficiency in antibody responses to Plasmodium falciparum antigens; however, prior studies have only focused on the anti...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2015-04, Vol.10 (4), p.e0124412-e0124412
Hauptverfasser:	Subramaniam, Krishanthi S, Skinner, Jeff, Ivan, Emil, Mutimura, Eugene, Kim, Ryung S, Feintuch, Catherine M, Portugal, Silvia, Anastos, Kathryn, Crompton, Peter D, Daily, Johanna P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adults Antibodies Antibody response Antigens Antigens, Protozoan - immunology B cells B-Lymphocytes - immunology CD19 antigen CD27 antigen CD4 antigen CD4-Positive T-Lymphocytes - metabolism Coinfection - immunology Comparative analysis Cytometry Female Flow cytometry Health aspects Health risks HIV HIV infections HIV Infections - immunology Human immunodeficiency virus Humans Immunologic Memory - immunology Immunological memory Infections Lymphocytes B Lymphocytes T Malaria Malaria, Falciparum - immunology Male Memory cells Plasmodium falciparum Plasmodium falciparum - immunology Plasmodium falciparum - pathogenicity Proteins T cells Vector-borne diseases Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	HIV infected individuals in malaria endemic areas experience more frequent and severe malaria episodes compared to non HIV infected. This clinical observation has been linked to a deficiency in antibody responses to Plasmodium falciparum antigens; however, prior studies have only focused on the antibody response to
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0124412