Effect of neoadjuvant chemotherapy on the serum levels of bone turnover markers in women with early-stage breast cancer

To evaluate effects of neoadjuvant chemotherapy on the bone turnover markers of preoperational breast cancer patients. Forty-one breast cancer patients (29 premenopausal and 12 postmenopausal) and 60 healthy women (30 premenopausal and 30 postmenopausal) aged 30-64 years, were evaluated for their bone status. Serum levels of the bone formation markers PINP and BAP, as well as the resorption markers ICTP and β-Crosslaps in addition to E2, FSH, 25(OH)D and PTH were measured at the initial diagnosis and at 24 hours after each four chemotherapy cycles. BMD T-scores were determined in 12 patients 6 months after the neoadjuvant chemotherapies. The baseline levels of both bone formation and resorption markers in premenopausal patients were higher than in premenopausal healthy women (p