Targets of Wnt/ß-catenin transcription in penile carcinoma

Penile squamous cell carcinoma (PeCa) is a rare malignancy and little is known regarding the molecular mechanisms involved in carcinogenesis of PeCa. The Wnt signaling pathway, with the transcription activator ß-catenin as a major transducer, is a key cellular pathway during development and in disea...

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Veröffentlicht in:	PloS one 2015, Vol.10 (4), p.e0124395
Hauptverfasser:	Arya, Manit, Thrasivoulou, Christopher, Henrique, Rui, Millar, Michael, Hamblin, Ruth, Davda, Reena, Aare, Kristina, Masters, John R, Thomson, Calum, Muneer, Asif, Patel, Hitendra R H, Ahmed, Aamir
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD1 - metabolism Arrays Basale biofag: 470 beta Catenin - genetics beta Catenin - metabolism Biomarkers c-Myc protein Cancer Carcinogenesis Carcinogens Case-Control Studies Catenin Cell cycle Cellebiologi: 471 Combinations (mathematics) Disease Gene Expression Regulation, Neoplastic Genes Genital cancers Heparan sulfate Hospitals Humans Immunohistochemistry Klinisk medisinske fag: 750 Localization Male Malignancy Matematikk og Naturvitenskap: 400 Matrilysin Matrix Metalloproteinase 7 - metabolism Medical research Medisinske Fag: 700 Molecular modelling Mutation Myc protein Neoplasm Grading Neoplasm Proteins - metabolism Onkologi: 762 Penile Neoplasms - genetics Penile Neoplasms - pathology Penis Permutations Prostate cancer Proteins Proto-Oncogene Proteins c-myc - metabolism Signal transduction Signaling Squamous cell carcinoma Surgery Tissues Transcription activation Transcription, Genetic Tumors Urology VDP Wnt protein Wnt4 Protein - genetics Wnt4 Protein - metabolism Womens health
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Zusammenfassung:	Penile squamous cell carcinoma (PeCa) is a rare malignancy and little is known regarding the molecular mechanisms involved in carcinogenesis of PeCa. The Wnt signaling pathway, with the transcription activator ß-catenin as a major transducer, is a key cellular pathway during development and in disease, particularly cancer. We have used PeCa tissue arrays and multi-fluorophore labelled, quantitative, immunohistochemistry to interrogate the expression of WNT4, a Wnt ligand, and three targets of Wnt-ß-catenin transcription activation, namely, MMP7, cyclinD1 (CD1) and c-MYC in 141 penile tissue cores from 101 unique samples. The expression of all Wnt signaling proteins tested was increased by 1.6 to 3 fold in PeCa samples compared to control tissue (normal or cancer adjacent) samples (p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0124395