Serum levels of oxylipins in achilles tendinopathy: an exploratory study

Linoleic acid-derived oxidation products are found in experimental pain models. However, little is known about the levels of such oxylipins in human pain. In consequence, in the present study, we have undertaken a lipidomic profiling of oxylipins in blood serum from patients with Achilles tendinopat...

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Veröffentlicht in:	PloS one 2015-04, Vol.10 (4), p.e0123114-e0123114
Hauptverfasser:	Gouveia-Figueira, Sandra, Nording, Malin L, Gaida, Jamie E, Forsgren, Sture, Alfredson, Håkan, Fowler, Christopher J
Format:	Artikel
Sprache:	eng
Schlagworte:	8,11,14-Eicosatrienoic Acid - blood Achilles Tendon - injuries Acids Adult Aged Arachidonic acid Biomarkers - blood Blood Case-Control Studies Eicosapentaenoic acid Ethanolamines - blood Fatty acids Female Growth factors Humans Linoleic acid Linoleic Acid - metabolism Linoleic Acids - blood Linolenic acid Lipids Male Metabolites Middle Aged Neurosciences Oxidation Oxidation-Reduction Oxylipins - blood Pain Pancreatitis Patients Pharmacology Risk Factors ROC Curve Rodents Serum levels Studies Tendinopathy - blood Tendinopathy - diagnosis Tendons Transient receptor potential proteins Ultrasonic imaging Young Adult
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Zusammenfassung:	Linoleic acid-derived oxidation products are found in experimental pain models. However, little is known about the levels of such oxylipins in human pain. In consequence, in the present study, we have undertaken a lipidomic profiling of oxylipins in blood serum from patients with Achilles tendinopathy and controls. A total of 34 oxylipins were analysed in the serum samples. At a significance level of P
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0123114