Declining incidence of candidemia and the shifting epidemiology of Candida resistance in two US metropolitan areas, 2008-2013: results from population-based surveillance

Recent reports have demonstrated a decline in bacterial bloodstream infections (BSIs) following adherence to central line insertion practices; however, declines have been less evident for BSIs due to Candida species. We conducted active, population-based laboratory surveillance for candidemia in met...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0120452-e0120452
Hauptverfasser:	Cleveland, Angela Ahlquist, Harrison, Lee H, Farley, Monica M, Hollick, Rosemary, Stein, Betsy, Chiller, Tom M, Lockhart, Shawn R, Park, Benjamin J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Antifungal agents Antifungal Agents - therapeutic use Bacterial infections Baltimore - epidemiology Candida Candida - drug effects Candida glabrata Candidemia Candidemia - drug therapy Candidemia - epidemiology Child Child, Preschool Comparative analysis Disease control Disease prevention Drug resistance Drug Resistance, Fungal - drug effects Echinocandins Epidemiology Female Fluconazole Fungicides Georgia - epidemiology Health aspects Health surveillance Human subjects Humans Incidence Infant Infant, Newborn Infection Infections Male Medical instruments Medical laboratories Medicine Metropolitan areas Microbial Sensitivity Tests Middle Aged Multidrug resistance Mutation Population Population Surveillance Public health Risk groups Surveillance Trends Young Adult
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Zusammenfassung:	Recent reports have demonstrated a decline in bacterial bloodstream infections (BSIs) following adherence to central line insertion practices; however, declines have been less evident for BSIs due to Candida species. We conducted active, population-based laboratory surveillance for candidemia in metropolitan Atlanta, GA and Baltimore, MD over a 5-year period. We calculated annual candidemia incidence and antifungal drug resistance rates. We identified 3,848 candidemia cases from 2008-2013. Compared with 2008, candidemia incidence per 100,000 person-years decreased significantly by 2013 in both locations (GA: 14.1 to 9.5, p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0120452