The TP73 gene polymorphism (rs4648551, A>G) is associated with diminished ovarian reserve

The TP73 gene polymorphism (rs4648551, A>G) is associated with diminished ovarian reserve

It's known that the members of the TP53 family are involved in the regulation of female reproduction. Studies in mice showed that the TP73 gene (member of this family) plays a role in the size of follicular pool, ovulation rate and maintenance of genomic stability. In the present study we analy...

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Veröffentlicht in:PloS one 2015-03, Vol.10 (3), p.e0120048-e0120048
Hauptverfasser: Vagnini, Laura Diniz, Renzi, Adriana, Oliveira-Pelegrin, Gabriela Ravanelli, Canas, Maria do Carmo Tomitão, Petersen, Claudia Guilhermino, Mauri, Ana Lucia, Oliveira, João Batista Alcantara, Baruffi, Ricardo Luiz Razera, Cavagna, Mario, Franco Junior, José Gonçalves
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Age
Alleles
Analysis
Anti-Mullerian Hormone - blood
Brazil
Case-Control Studies
Cell cycle
Data processing
Defects
Deoxyribonucleic acid
DNA
DNA-Binding Proteins - genetics
Female
Follicles
Gene expression
Gene Frequency
Gene polymorphism
Genes
Genetic aspects
Genetic Association Studies
Genetic polymorphisms
Genotype
Genotypes
Humans
In vitro fertilization
Infertility
Nuclear Proteins - genetics
Ovarian Follicle
Ovarian Reserve - genetics
Ovary
Ovulation
Ovulation Induction
p53 Protein
Patients
Polymorphism
Polymorphism, Single Nucleotide
Reproductive technologies
Stability analysis
Studies
Tumor Protein p73
Tumor proteins
Tumor Suppressor Proteins - genetics
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Zusammenfassung:It's known that the members of the TP53 family are involved in the regulation of female reproduction. Studies in mice showed that the TP73 gene (member of this family) plays a role in the size of follicular pool, ovulation rate and maintenance of genomic stability. In the present study we analyzed data from 605 patients with ≤ 37 years attending their first intracytoplasmic sperm injection (ICSI). The association between the TP73 polymorphism (rs4648551, A>G) and the following parameters related to ovarian reserve, like age, antral follicular count (AFC), anti-Mullerian hormone levels (AMH) and ovarian response prediction index (ORPI) was evaluated. Our results showed an association of the AA genotype with diminished ovarian reserve (AMH
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0120048