Circulating level of CTRP1 in patients with nonalcoholic fatty liver disease (NAFLD): is it through insulin resistance?

Nonalcoholic fatty liver disease (NAFLD) is considered as one of the most common liver diseases. It is robustly linked to obesity and insulin resistance and is regarded as hepatic manifestation of metabolic syndrome (MetS). Adipokines are involved in the pathophysiology of liver diseases. The aim of...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0118650-e0118650
Hauptverfasser:	Shabani, Parisa, Naeimi Khaledi, H, Beigy, Maani, Emamgholipour, Solaleh, Parvaz, Eskandar, Poustchi, Hossein, Doosti, Mahmood
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Alcohol use Biochemistry Biomarkers Blood glucose Body mass Body mass index Body size Cardiovascular disease Case-Control Studies Cholesterol Complement component C1q Coronary vessels Correlation Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - metabolism Diabetes therapy Disease resistance Enzyme-linked immunosorbent assay Fasting Fatty liver Glucose Hepatitis Homeostasis Humans Hypoglycemic agents Insulin Insulin Resistance Liver Liver - metabolism Liver - pathology Liver diseases Medicine Metabolic syndrome Metabolism Middle Aged Non-alcoholic Fatty Liver Disease - blood Non-alcoholic Fatty Liver Disease - complications Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology Obesity Pathogenesis Patients Proteins Proteins - metabolism Rodents Stiffness Studies Tumor necrosis factor Tumor necrosis factor-TNF
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Zusammenfassung:	Nonalcoholic fatty liver disease (NAFLD) is considered as one of the most common liver diseases. It is robustly linked to obesity and insulin resistance and is regarded as hepatic manifestation of metabolic syndrome (MetS). Adipokines are involved in the pathophysiology of liver diseases. The aim of this study was to evaluate the plasma concentrations of CTRP1 (complement-C1q TNF-related protein 1) in 22 patients with NAFLD, 22 patients with type 2 diabetes mellitus (T2DM), 22 patients with NAFLD+T2DM and 21 healthy controls, as well as their correlation with the level of metabolic and hepatic parameters. Plasma concentration of CTRP1 was measured with ELISA method. Plasma concentration of CTRP1 in patients with NAFLD, T2DM and NAFLD+T2DM were significantly higher than healthy subjects (p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0118650