Serum amyloid a truncations in type 2 diabetes mellitus

Using mass spectrometric immunoassay, the abundance of SAA truncations relative to the native variants was examined in plasma of 91 participants with type 2 diabetes and chronic kidney disease and 69 participants without diabetes. The ratio of SAA 1.1 (missing N-terminal arginine) to native SAA 1.1...

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Veröffentlicht in:	PloS one 2015-01, Vol.10 (1), p.e0115320-e0115320
Hauptverfasser:	Yassine, Hussein N, Trenchevska, Olgica, He, Huijuan, Borges, Chad R, Nedelkov, Dobrin, Mack, Wendy, Kono, Naoko, Koska, Juraj, Reaven, Peter D, Nelson, Randall W
Format:	Artikel
Sprache:	eng
Schlagworte:	Abundance Adult Aged Aged, 80 and over Amyloid Antigens Arginine Arginine - metabolism Biochemistry Blood cholesterol Cholesterol Cholesterol, HDL - blood Chronic illnesses Chronic kidney failure Correlation analysis Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - blood Diabetics Family medical history Female Females Hemoglobin Hemoglobins High density lipoprotein Humans Immunoassay Isoforms Kidney diseases Lipids Male Males Middle Aged Proteins Relative abundance Scientific imaging Serine Serum Amyloid A Protein - metabolism Spectrometry Studies Type 2 diabetes Weight control
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Zusammenfassung:	Using mass spectrometric immunoassay, the abundance of SAA truncations relative to the native variants was examined in plasma of 91 participants with type 2 diabetes and chronic kidney disease and 69 participants without diabetes. The ratio of SAA 1.1 (missing N-terminal arginine) to native SAA 1.1 was lower in diabetics compared to non-diabetics (p = 0.004), and in males compared to females (p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0115320